Molecular structure of Sarafotoxin 6c, CAS Number: 121695-87-2
Sarafotoxin 6c (CAS 121695-87-2)
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Alternate Names:
Sarafotoxins s6; SRTX-c
Application:
Sarafotoxin 6c is a selective endothelin subtype B receptor agonist that induces muscle contractions
CAS Number:
121695-87-2
Purity:
≥95%
Molecular Weight:
2515.75
Molecular Formula:
C103H147N27O37S5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sarafotoxin 6c is a peptide toxin that functions as a potent vasoconstrictor. It exerts its mechanism of action by binding to and activating endothelin receptors. This interaction leads to the activation of G-proteins and subsequent signaling cascades, resulting in the constriction of blood vessels. Sarafotoxin 6c′s mechanism of action involves the modulation of calcium channels and the release of intracellular calcium, ultimately leading to smooth muscle contraction. This peptide toxin plays a role in the regulation of vascular tone and blood pressure, making it useful for studying cardiovascular physiology and pharmacology.
Sarafotoxin 6c (CAS 121695-87-2) References
- Influence of endothelins and sarafotoxin 6c and L-NAME on renal vasoconstriction in the anaesthetized rat. | Marshall, JL. and Johns, EJ. 1999. Br J Pharmacol. 128: 809-15. PMID: 10516666
- Arterial pressure response to endothelin-1 and sarafotoxin 6c in rescued endothelin-B-deficient rats. | Pollock, DM., et al. 2000. J Cardiovasc Pharmacol. 36: S82-5. PMID: 11078343
- An improved procedure for the preparation of the endothelin-B-receptor ligand sarafotoxin 6c. | Langlois, C., et al. 2000. J Cardiovasc Pharmacol. 36: S290-1. PMID: 11078401
- Sarafotoxin 6c protects against ischaemia-induced cardiac arrhythmias in vivo and in vitro in the rat. | Crockett, TR., et al. 2000. J Cardiovasc Pharmacol. 36: S297-9. PMID: 11078403
- Heterogeneity of endothelin-sarafotoxin receptors mediating contraction of pig coronary artery. | Harrison, VJ., et al. 1992. Br J Pharmacol. 105: 511-3. PMID: 1320978
- Replacement of lysine-181 by aspartic acid in the third transmembrane region of endothelin type B receptor reduces its affinity to endothelin peptides and sarafotoxin 6c without affecting G protein coupling. | Zhu, G., et al. 1992. J Cell Biochem. 50: 159-64. PMID: 1429881
- Sarafotoxin 6c (S6c) reduces infarct size and preserves mRNA for the ETB receptor in the ischemic/reperfused myocardium of anesthetized rats. | Crockett, TR., et al. 2004. J Cardiovasc Pharmacol. 44: 148-54. PMID: 15243294
- Pretreatment with sarafotoxin 6c prior to coronary occlusion protects against infarction and arrhythmias via cardiomyocyte mitochondrial K(ATP) channel activation in the intact rabbit heart during ischemia/reperfusion. | Das, B., et al. 2007. Cardiovasc Drugs Ther. 21: 243-51. PMID: 17520332
- Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat. | McMahon, TJ., et al. 1991. J Appl Physiol (1985). 71: 2019-25. PMID: 1761504
- Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. | Li, M., et al. 2008. Am J Physiol Regul Integr Comp Physiol. 295: R1546-54. PMID: 18768769
- Actions of endothelins and sarafotoxin 6c in the rat isolated perfused lung. | Lal, H., et al. 1995. Br J Pharmacol. 115: 653-9. PMID: 7582486
- Investigation of the contributions of nitric oxide and prostaglandins to the actions of endothelins and sarafotoxin 6c in rat isolated perfused lungs. | Lal, H., et al. 1996. Br J Pharmacol. 118: 1931-8. PMID: 8864526
- Insulin and IGF-I attenuate the coronary vasoconstrictor effects of endothelin-1 but not of sarafotoxin 6c. | Hasdai, D., et al. 1998. Cardiovasc Res. 39: 644-50. PMID: 9861307
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GPR10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sarafotoxin 6c, 100 µg | sc-397331 | 100 µg | $423.00 | |||
Sarafotoxin 6c, 500 µg | sc-397331A | 500 µg | $816.00 | |||
Sarafotoxin 6c, 1 mg | sc-397331B | 1 mg | $1533.00 | |||
Sarafotoxin 6c, 2.5 mg | sc-397331C | 2.5 mg | $2550.00 |