GPAM Activators
GPAM Activators encompass a variety of biochemical entities that collectively contribute to the enhanced functionality of GPAM, a crucial enzyme in glycerolipid biosynthesis. Direct activators such as Oleic Acid, Linoleic Acid, and Palmitic Acid serve as substrates for GPAM, facilitating its catalytic action in the synthesis of triglycerides and phospholipids, integral components of cellular membranes and energy storage mechanisms. Similarly, Glycerophosphoric acid and Acetyl-CoA, as essential substrates, play pivotal roles in enabling GPAM to catalyze the formation of phosphatidic acid, a key intermediate in lipid biosynthesis. The availability of these substrates directly dictates the rate of GPAM-mediated lipid synthesis, thereby modulating the lipid composition and functionality of cellular membranes.
Apart from these direct substrates, GPAM activity is also modulated by indirect activators that influence lipid metabolism pathways. Insulin, by upregulating lipogenic enzymes, fosters an environment conducive to lipid synthesis, subsequently enhancing GPAM's role in this process. L-Leucine, through its activation of the mTOR pathway, and Thiazolidinediones (like Rosiglitazone), acting as PPARγ agonists, further contribute to the upregulation of lipogenic genes, including those involved in glycerolipid biosynthesis where GPAM operates. Additionally, metabolic intermediates like D(+)Glucose, Anhydrous and Ethanol, through their roles in providing acetyl-CoA, indirectly support GPAM function.NAD+, Free Acid, essential in redox reactions, and Cholesterol, influential in modulating membrane composition, further underscore the complex network of biochemical interactions that govern GPAM activity. This intricate interplay of direct substrates and indirect activators highlights the multifaceted regulatory mechanisms that enhance GPAM's essential role in lipid biosynthesis, crucial for maintaining cellular integrity and energy homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, directly enhances GPAM activity by serving as a substrate for the enzyme. GPAM catalyzes the initial step in glycerolipid biosynthesis, and the presence of Oleic Acid leads to increased enzymatic activity in this pathway. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $33.00 $63.00 $163.00 $275.00 | 4 | |
Linoleic Acid, a polyunsaturated fatty acid, serves as another substrate for GPAM, enhancing its activity. The incorporation of Linoleic Acid by GPAM into glycerolipids is crucial for the synthesis of membrane lipids and signaling molecules. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
Palmitic Acid is a saturated fatty acid that acts as a substrate for GPAM, thus directly enhancing its enzymatic activity. GPAM's role in incorporating Palmitic Acid into triglycerides and phospholipids is vital for lipid metabolism and energy storage. | ||||||
Glycerophosphoric acid | 57-03-4 | sc-353615 sc-353615A | 5 g 25 g | $311.00 $872.00 | ||
Glycerophosphoric acid is a direct substrate for GPAM in the synthesis of glycerolipids. Its presence is essential for GPAM to catalyze the formation of phosphatidic acid, a key intermediate in lipid biosynthesis. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can indirectly enhance GPAM activity by upregulating lipogenic enzymes and pathways. This hormonal influence promotes lipid synthesis, leading to increased GPAM activity in glycerolipid biosynthesis. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
L-Leucine, an essential amino acid, can indirectly enhance GPAM activity by activating the mTOR pathway, which plays a role in lipid synthesis and metabolism. This activation can lead to upregulated GPAM activity in glycerolipid biosynthesis. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Thiazolidinediones, specifically Rosiglitazone, act as PPARγ agonists and can indirectly enhance GPAM activity by upregulating lipogenic genes, including those involved in glycerolipid biosynthesis, in which GPAM is a key enzyme. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $37.00 $194.00 $64.00 | 5 | |
D(+)Glucose, Anhydrous, through its role in glycolysis and subsequent acetyl-CoA production, indirectly influences GPAM activity. Increased glucose metabolism enhances the availability of substrates for fatty acid synthesis, thereby supporting GPAM function. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+, Free Acid, as a coenzyme in redox reactions, indirectly influences GPAM activity. It is essential in metabolic pathways that provide substrates for lipid biosynthesis, thereby supporting GPAM function in glycerolipid synthesis. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol, though not a direct substrate, can indirectly enhance GPAM activity. Its role in modulating membrane fluidity and composition can influence lipid biosynthetic pathways, where GPAM is a key enzyme. | ||||||