Gonadotropin α Inhibitors
Chemical inhibitors of Gonadotropin α act by disrupting the synthesis of steroid hormones, which are the end products that Gonadotropin α stimulates. Trilostane, operating as an inhibitor of 3β-hydroxysteroid dehydrogenase, hinders the conversion of precursors into active steroids, thus indirectly diminishing Gonadotropin α's role in promoting steroidogenesis. Aminoglutethimide exerts its inhibitory effects by blocking the enzyme P450scc, which catalyzes the initial step of converting cholesterol into pregnenolone, a precursor for all steroid hormones. Consequently, this action attenuates the stimulatory effect of Gonadotropin α on steroid hormone production. Ketoconazole, although primarily known as an antifungal, also disrupts steroid synthesis by inhibiting CYP17A1, an enzyme critical for the production of androgens and estrogens, thereby counteracting the biological activity of Gonadotropin α.
Further down the steroidogenic pathway, metyrapone selectively targets 11β-hydroxylase, crucial for cortisol synthesis, while etomidate and osilodrostat also inhibit this enzyme, leading to altered adrenal hormone profiles and indirectly suppressing the functional activity of Gonadotropin α. Mitotane, with its multifaceted effects on steroidogenesis, can lead to a broad reduction in adrenal steroid output, which falls under the regulatory domain of Gonadotropin α. Aromatase inhibitors such as exemestane, letrozole, and anastrozole reduce estrogen levels by preventing the conversion of androgens into estrogens, a key process that Gonadotropin α is known to stimulate. Consequently, these inhibitors can suppress the functional aspects of Gonadotropin α related to estrogen production. Lastly, finasteride disrupts the conversion of testosterone to dihydrotestosterone by inhibiting 5α-reductase, thus altering the androgen milieu that is tightly regulated by Gonadotropin α, leading to a downregulation of the protein's functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trilostane | 13647-35-3 | sc-208469 sc-208469A | 10 mg 100 mg | $228.00 $1217.00 | 2 | |
Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase, which is involved in the biosynthesis of steroids. Gonadotropin α (Gonadotropin α) is a glycoprotein that stimulates the production of steroid hormones. By inhibiting steroidogenesis, trilostane can indirectly reduce the biological activity of Gonadotropin α as it reduces the steroid output that Gonadotropin α aims to increase. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits the enzyme P450scc, which converts cholesterol to pregnenolone, the first step in the synthesis of all steroid hormones. Since Gonadotropin α stimulates the synthesis of steroid hormones, the inhibition of their synthesis by aminoglutethimide can result in a functional inhibition of Gonadotropin α's biological activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole is known primarily as an antifungal agent but also has potent inhibition of steroidogenic enzymes such as CYP17A1. It can reduce the synthesis of steroid hormones which are the end products stimulated by Gonadotropin α, thereby leading to a functional inhibition of Gonadotropin α. | ||||||
Metyrapone | 54-36-4 | sc-200597 sc-200597A sc-200597B | 200 mg 500 mg 1 g | $26.00 $57.00 $88.00 | 4 | |
Metyrapone selectively inhibits 11β-hydroxylase, an enzyme involved in cortisol synthesis. Reduced cortisol levels can lead to an increased release of ACTH, which can disrupt the feedback mechanism and indirectly affect the function of Gonadotropin α by altering the hormonal milieu it interacts with. | ||||||
Abiraterone | 154229-19-3 | sc-460288 | 10 mg | $276.00 | ||
Abiraterone is a CYP17 inhibitor that blocks the production of androgens, which are one of the targets of Gonadotropin α's stimulatory effect. By inhibiting androgen synthesis, abiraterone can indirectly cause the functional inhibition of Gonadotropin α. | ||||||
Etomidate | 33125-97-2 | sc-203577 | 10 mg | $126.00 | ||
Etomidate is a potent inhibitor of 11β-hydroxylase and other adrenal enzymes. By inhibiting cortisol synthesis, it can disrupt the HPA axis, indirectly affecting the regulation and function of Gonadotropin α. | ||||||
Mitotane | 53-19-0 | sc-205754 sc-205754A | 100 mg 1 g | $72.00 $166.00 | 1 | |
Mitotane affects several steps in steroidogenesis and can reduce adrenal output of steroid hormones. As Gonadotropin α's function is related to stimulating the production of these hormones, mitotane's action can result in a decrease in Gonadotropin α's functional activity. | ||||||
Exemestane | 107868-30-4 | sc-203045 sc-203045A | 25 mg 100 mg | $134.00 $411.00 | ||
Exemestane is an aromatase inhibitor, reducing the synthesis of estrogens from androgens. Gonadotropin α stimulates the synthesis of estrogens in the ovaries, and the inhibition of their production by exemestane can lead to a functional inhibition of Gonadotropin α. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $87.00 $147.00 | 5 | |
Letrozole is another aromatase inhibitor that lowers estrogen production. Since Gonadotropin α is involved in the regulation of estrogen synthesis, the inhibition by letrozole can lead to a functional inhibition of Gonadotropin α. | ||||||
Anastrozole | 120511-73-1 | sc-217647 | 10 mg | $92.00 | 1 | |
Anastrozole, by inhibiting aromatase, decreases estrogen biosynthesis. Given that Gonadotropin α stimulates the synthesis of estrogens, anastrozole's action can lead to the functional inhibition of Gonadotropin α by reducing its target hormone's production. | ||||||