GOLGA6B Activators
GOLGA6B Activators are a group of chemical compounds that influence the functional activity of GOLGA6B through specific signaling pathways associated with the Golgi apparatus. For instance, Forskolin and N6-Benzoyladenosine, by raising intracellular cAMP levels, enhance GOLGA6B function through PKA activation, which is known to phosphorylate proteins involved in Golgi apparatus dynamics. PMA and Okadaic Acid, through activating PKC and inhibiting protein phosphatases respectively, lead to an increase in the phosphorylation state of proteins that could include GOLGA6B or its associated factors, thereby potentially enhancing GOLGA6B's role in the structural integrity and vesicular trafficking of the Golgi. Brefeldin A's disruption of Golgi structure further necessitates the activation of proteins like GOLGA6B to facilitate the reassembly and maintenance of Golgi function. Similarly, Thapsigargin and Ionomycin, by modulating intracellular calcium levels, activate calcium-signaling pathways that can influence Golgi apparatus operations, indirectly contributing to the enhancement of GOLGA6B's role in this organelle.
Nocodazole and Monensin, by perturbing microtubule dynamics and altering ion gradients, respectively, challenge the structural status of the Golgi, potentially leading to a compensatory upregulation of GOLGA6B activity in response to these stressors. Lithium Chloride, with its inhibitory action on GSK3, could lead to the stabilization and enhanced activity of proteins involved in the maintenance of the Golgi, including GOLGA6B. The provision of energy by ATP is crucial for maintaining Golgi function, and its availability is directly linked to the enhancement of GOLGA6B activity. Lastly, EGF, through its activation of the EGFR pathway, exerts downstream effects that can enhance GOLGA6B's regulatory functions associated with Golgi dynamics, thereby indirectly contributing to the protein's enhanced functional activity. Each of these activators, through their unique mechanisms, serves to enhance the functional activity of GOLGA6B, highlighting the intricate network of signaling pathways that converge on the regulation of the Golgi apparatus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing levels of cyclic AMP (cAMP) within cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate a multitude of substrates including factors that influence the Golgi apparatus and its associated proteins, such as GOLGA6B. This phosphorylation can enhance the functional activity of GOLGA6B in the regulation of Golgi trafficking and maintenance. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol (DAG) analog that activates protein kinase C (PKC). PKC phosphorylation targets may include proteins that interact with the Golgi apparatus, potentially enhancing the activity of GOLGA6B in the maintenance of Golgi structure and function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. The inhibition of phosphatase activity can result in increased phosphorylation levels of various proteins, indirectly enhancing the activity of GOLGA6B by promoting phosphorylation-dependent processes within the Golgi apparatus. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus by inhibiting ADP-ribosylation factors (ARFs). The subsequent reassembly of the Golgi may involve enhanced activity of GOLGA6B to restore Golgi functionality. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that raises intracellular calcium levels, leading to the activation of calcium-dependent signaling pathways. These pathways can modulate Golgi apparatus function, thereby potentially enhancing GOLGA6B activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization, affecting vesicle transport and the structural integrity of the Golgi apparatus. Reorganization of the Golgi may upregulate GOLGA6B activity as part of a cellular response to maintain Golgi function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK3). GSK3 inhibition can result in the stabilization and activity enhancement of various proteins, including those involved in Golgi apparatus function, potentially enhancing GOLGA6B activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling cascades. These cascades may influence Golgi apparatus function and thus enhance GOLGA6B activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore that alters intracellular ion gradients, particularly sodium and hydrogen ions, impacting Golgi function. This alteration could enhance GOLGA6B activity by affecting Golgi pH and trafficking processes. | ||||||