GODZ Activators

The category of GODZ Activators includes a variety of chemical compounds that, while not directly activating GODZ, can potentially influence its activity through modulation of lipid metabolism, cellular signaling pathways, and inflammatory responses. GODZ, being a palmitoyltransferase, plays a critical role in the post-translational modification of proteins, specifically through the addition of palmitate groups. The first group of these compounds includes direct substrates and modulators of lipid metabolism, such as Palmitic Acid, 2-Bromopalmitate, Cerulenin, Cholesterol, Myristic Acid, and Omega-3 Fatty Acids. These substances are directly or indirectly involved in the process of protein palmitoylation. For example, Palmitic Acid is a key substrate for the palmitoylation process, and its availability can directly influence GODZ's enzymatic activity.

Another significant group comprises compounds that modulate cellular metabolic and signaling pathways, including Forskolin, AMP-activated Protein Kinase activators, Lipopolysaccharide, Insulin, Nitric Oxide donors, and Calcium Ionophores. These substances can influence various cellular processes and pathways that may intersect with the function of GODZ. For instance, Insulin regulates metabolic pathways that can affect the availability of fatty acids for palmitoylation, while AMPK activators can modulate metabolic states of the cell, potentially impacting GODZ activity.