GNPDA2 Activators
A spectrum of compounds involved in O-GlcNAc transferase regulation and protein O-GlcNAcylation demonstrate approaches to enhance GNPDA2 function. Glucosamine and related precursors like UDP-GlcNAc stimulate O-GlcNAc transferase activity central to GNPDA2 modification. Small molecules directly activating O-GlcNAc transferase apply a direct mechanism. Interestingly, GFAT and G6PT inhibitors paradoxically increase the UDP-GlcNAc pool indirectly stimulating O-GlcNAc transferase. Identification of OGT activators and GlcNAc derivatives unveil means of fine-tuning O-GlcNAc transferase and pathways impacting GNPDA2 activity.
Considering post-translational regulation governs GNPDA2 functions, targeting its O-GlcNAcylation state presents opportunities. Compounds preserving or optimizing these dynamic modifications offer precision to elucidate effects on GNPDA2 downstream of O-GlcNAc transferase. Glucosamine and Thiamet-G activating central pathway nodes generate broad impacts warranting refinement. Interrogating UDP-GlcNAc modulators shed light on localized modifications.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Glucosamine | 3416-24-8 | sc-278917A sc-278917 | 1 g 10 g | $197.00 $764.00 | ||
Glucosamine is a precursor in the hexosamine biosynthesis pathway, which generates UDP-GlcNAc that stimulates O-GlcNAc transferase activity. O-GlcNAcylation of proteins regulates their functions, and O-GlcNAc transferase enhances GNPDA2 activity through O-GlcNAc modifications. | ||||||
N-Acetyl-D-glucosamine | 7512-17-6 | sc-286377 sc-286377B sc-286377A | 50 g 100 g 250 g | $92.00 $159.00 $300.00 | 1 | |
Uridine 5'-diphospho-N-acetylglucosamine (UDP-GlcNAc) donates the GlcNAc moiety for O-GlcNAc transferase-mediated protein modification. Elevated UDP-GlcNAc stimulates O-GlcNAc transferase and thus enhances GNPDA2 activity via O-GlcNAcylation. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $183.00 | 3 | |
STF-31 indirectly stimulates O-GlcNAc transferase as a GFAT inhibitor that increases the UDP-GlcNAc pool. Greater UDP-GlcNAc substrate availability enhances O-GlcNAc transferase activity and GNPDA2 O-GlcNAcylation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
The proteasome inhibitor MG-132 stabilizes proteins undergoing O-GlcNAcylation, allowing increased modification of targets like GNPDA2 to enhance its functional output. | ||||||
Thiamet G | 1009816-48-1 | sc-224307 sc-224307A | 1 mg 5 mg | $51.00 $94.00 | 1 | |
Thiamet-G activates glucose-6-phosphate transaminase, elevating UDP-GlcNAc levels for O-GlcNAc transferase to modify GNPDA2 and enhance its activity. | ||||||