GMF-γ inhibitors belong to a specialized chemical class designed to target and modulate the activity of Glia Maturation Factor gamma (GMF-γ), a protein that plays a crucial role in cellular processes within the central nervous system. GMF-γ is known for its involvement in neuroinflammatory responses and has been implicated in various neurodegenerative disorders. The inhibitors are meticulously engineered compounds designed to selectively bind to GMF-γ, thereby impeding its normal cellular functions. By disrupting the signaling pathways associated with GMF-γ, these inhibitors aim to offer a nuanced approach to influencing cellular processes implicated in neuroinflammation.
GMF-γ inhibitors exhibit a diverse array of chemical compositions, often characterized by specific functional groups and molecular motifs crucial for their binding affinity to the GMF-γ protein. The design of these inhibitors involves a meticulous understanding of the three-dimensional structure of GMF-γ, ensuring precise interactions with key residues in the protein's binding pocket. Through this targeted approach, GMF-γ inhibitors hold promise in contributing to our understanding of the underlying molecular mechanisms involved in neuroinflammation, paving the way for further research in the quest to unravel the complexities of neurological disorders. As the scientific community continues to delve into the intricacies of GMF-γ inhibitors, their potential applications may extend beyond basic research, offering insights into the development of innovative strategies for addressing neurological challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Binds to the barbed ends of actin filaments, preventing polymerization and elongation, thereby disrupting cytoskeletal organization and cell migration. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to monomeric G-actin, sequestering it, and preventing its polymerization into filaments, which can affect cytoskeletal dynamics and cellular processes dependent on actin. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Severs actin filaments and caps the barbed ends, which can lead to a breakdown of the actin cytoskeleton and affect cellular functions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibitor of Rho-associated protein kinase (ROCK), indirectly influencing actin cytoskeleton dynamics through the Rho/ROCK pathway. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin nucleation and elongation, impacting the formation of actin structures. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Inhibits myosin II, a motor protein that interacts with actin filaments for muscle contraction and cell motility, impacting cellular processes that rely on actin-myosin interactions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), which is involved in the phosphorylation of myosin light chains, a process crucial for actin-myosin contraction. | ||||||