Gm996 Activators
Apical Junction Component 1 Activators are a group of chemical compounds that can indirectly enhance the functional activity of apical junction component 1 by influencing the cellular processes and signaling pathways it is directly involved in. Compounds such as Calcium ionophore A23187 and Thapsigargin focus on manipulating intracellular calcium levels, which is a critical second messenger in the signaling pathways that regulate cell-cell adhesion and the stability of apical junctional complexes. By increasing the intracellular calcium concentration, these compounds enhance the phosphorylation state of proteins that interact with apical junction component 1, leading to its activation and the stabilization of adherens junctions.
Other chemicals in this class, like Jasplakinolide and Blebbistatin, target the cytoskeletal components and their regulatory mechanisms to influence the activity of apical junction component 1. Jasplakinolide stabilizes actin filaments, which is essential for the mechanical tension and integrity of cell junctions, thereby promoting the association and activation of apical junction component 1. In contrast, Blebbistatin inhibits myosin II activity to reduce contractility at cell junctions, leading to a stabilization effect that can activate apical junction component 1. Similarly, inhibitors like Y-27632 and ML-7 act on kinases that regulate myosin light chain phosphorylation, a process central to the control of cell tension and junctional stability, thus enhancing the activity of apical junction component 1.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium concentration, enhancing calcium-dependent protein kinase signaling which, in turn, can lead to activation of apical junction component 1 by stabilizing junctional complexes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels, which can enhance the phosphorylation of proteins involved in adherens junctions and potentially activate apical junction component 1. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments, which can increase the tension at cell junctions and may enhance the activity of apical junction component 1 by promoting its association with the cytoskeleton. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor that reduces phosphorylation of myosin light chain, which can decrease tension at cell junctions, potentially leading to activation of apical junction component 1 by stabilizing junctions. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a phosphatase inhibitor that prevents dephosphorylation of proteins associated with cell junctions, which can lead to enhanced activity of apical junction component 1 through stabilization of these complexes. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase that lowers phosphorylation of myosin light chain, which can lead to the activation of apical junction component 1 by promoting cell junction stability. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 inhibits Rac1, which can affect the organization of the actin cytoskeleton. This can enhance the activity of apical junction component 1 by influencing the assembly of junctional complexes. | ||||||
PF-562271 | 717907-75-0 | sc-478488 sc-478488A sc-478488B | 5 mg 10 mg 50 mg | $312.00 $474.00 $1124.00 | 3 | |
PF-562271 is a focal adhesion kinase inhibitor that can lead to altered cell adhesion dynamics, potentially enhancing apical junction component 1 activity by affecting cell junction composition and stability. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II activity, leading to reduced contractility at cell junctions, which can activate apical junction component 1 by stabilizing cell-cell contacts. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is a farnesyltransferase inhibitor that can affect Rho family GTPase signaling. This can lead to activation of apical junction component 1 by influencing cytoskeletal dynamics and enhancing junction stability. | ||||||