Gm732 Activators
WAVE homology in membrane protrusions (Wmp) activators consist of compounds that influence the actin cytoskeleton and related signaling pathways, leading to enhanced functional activity of Wmp. Compounds such as Jasplakinolide and Phalloidin directly bind to actin, promoting filament stabilization, which can indirectly enhance Wmp activity as it operates in conjunction with the Arp2/3 complex to facilitate actin polymerization. Stabilization of actin filaments by these compounds can create a cellular environment that necessitates the involvement of Wmp to extend or create new filaments, thereby enhancing its functional role in actin dynamics.
Other chemicals, like CK-666 and Cytochalasin D, disrupt normal actin polymerization through various mechanisms, leading to cellular compensatory responses that can include the upregulation of Wmp activity. In response to actin dynamics disruption, Wmp may be activated to restore or maintain cellular structures such as membrane protrusions and cell motility. Compounds such as Y-27632 and Blebbistatin interfere with actomyosin contractility, which could lead to increased reliance on Wmp to promote actin polymerization in the context of altered cellular mechanics. Furthermore, inhibitors of small GTPases like NSC 23766 and ML141 may indirectly enhance Wmp activity by affecting upstream regulators of actin polymerization, creating a feedback loop that drives the activity of Wmp as the cell seeks to compensate for the inhibited signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and can lead to the activation of the Arp2/3 complex, which WAVE homology in membrane protrusions (Wmp) is known to interact with to promote actin polymerization. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds to and stabilizes F-actin, preventing its depolymerization. This stabilization can enhance the activity of the Arp2/3 complex, subsequently enhancing the activity of Wmp in actin polymerization. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which leads to compensatory mechanisms within the cell to maintain actin dynamics, potentially increasing the functional activity of Wmp to sustain cell motility and structure. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers, preventing their polymerization. This disruption of actin dynamics can lead to enhanced activation of Wmp as the cell attempts to restore equilibrium. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D blocks actin polymerization and can induce an increase in nucleation sites for actin assembly, which Wmp can capitalize on to enhance actin polymerization. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor, leading to reduced tension on actin filaments and potentially increasing the necessity for Wmp's role in actin polymerization. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 specifically inhibits Rac1 GTPase binding, which is upstream of Wmp. The inhibition of Rac1 can enhance the activity of Wmp as a feedback mechanism to maintain actin dynamics. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a Cdc42 inhibitor, which may lead to an upregulation of Wmp's activity as the cell compensates for disrupted actin polymerization signals. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin inhibits myosin II, which may increase the requirement for Wmp activity to support actin polymerization in the absence of myosin II-mediated contractility. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which can lead to a reorganization of the actin cytoskeleton and a potential increase in Wmp activity as part of the compensatory response. | ||||||