GM2-AP Inhibitors
Chemical inhibitors of GM2-AP can exert their inhibitory effects through various mechanisms affecting the protein's lipid environment and cellular trafficking. Methyl-β-cyclodextrin affects GM2-AP functionality by extracting cholesterol from cellular membranes, thereby disrupting lipid rafts where GM2-AP is active. Similarly, Filipin binds to cholesterol, perturbing the lipid rafts and consequently inhibiting the raft-associated activities of GM2-AP. U18666A disrupts intracellular cholesterol trafficking, leading to its accumulation and potential disturbance of the cholesterol-rich microenvironments crucial for GM2-AP activity. Genistein inhibits tyrosine kinases that may be involved in GM2-AP's localization and function, suggesting an indirect means of inhibition through interference with protein trafficking and cellular signaling pathways. Progesterone modulates sphingolipid metabolism, which can affect GM2-AP by altering the lipid composition of the membranes where GM2-AP functions.
Chlorpromazine and Imipramine both act as inhibitors of acid sphingomyelinase, which in turn can lead to changes in lipid composition, affecting GM2-AP indirectly by disrupting its lipid-dependent processes. GW4869 similarly inhibits acid sphingomyelinase, influencing the lipid composition and potentially the lipid raft domains essential for GM2-AP's activity. NB-DNJ and D-PDMP are inhibitors of glucosylceramide synthase, which can impact GM2-AP by reducing the synthesis of glycosphingolipids, thus affecting the pool of lipid substrates required for GM2-AP's function. Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase, which can affect GM2-AP by modifying its conformation or trafficking, processes that rely on calcium. Lastly, Bafilomycin A1 inhibits the vacuolar type H+-ATPase, which can increase lysosomal pH, negatively impacting the acidic environment GM2-AP needs for optimal functioning.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin can deplete cholesterol from cellular membranes, potentially disrupting lipid rafts. Since GM2-AP's function in lipid transport and hydrolase facilitation can be raft-dependent, this agent can inhibit GM2-AP by disrupting its lipid raft-associated activity. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A is an intracellular cholesterol transport inhibitor that can lead to the accumulation of cholesterol in late endosomes and lysosomes. This can indirectly inhibit GM2-AP by disturbing the cholesterol-rich microenvironments that are necessary for its optimal activity. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
Filipin complexes with cholesterol, disrupting lipid rafts within cellular membranes. Given that GM2-AP operates in association with such rafts, Filipin can inhibit GM2-AP by perturbing its lipid raft-mediated processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein can inhibit tyrosine kinases. As tyrosine phosphorylation can regulate trafficking and function of proteins, Genistein can inhibit GM2-AP by interfering with its proper localization and function. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone can modulate sphingolipid metabolism. It can inhibit GM2-AP by altering the sphingolipid composition of cellular membranes, thus affecting the lipid environment where GM2-AP exerts its function. | ||||||
Imipramine hydrochloride | 113-52-0 | sc-207753 sc-207753B sc-207753A | 100 mg 1 g 5 g | $26.00 $45.00 $103.00 | 5 | |
Imipramine is known to inhibit acid sphingomyelinase (ASM). Since GM2-AP is involved in the metabolism of gangliosides and sphingolipids, inhibition of ASM by Imipramine can result in altered lipid composition, indirectly inhibiting GM2-AP activity. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine can inhibit acid sphingomyelinase and can also influence the assembly of lipid rafts. This inhibition can indirectly influence GM2-AP activity by disrupting the lipid environments necessary for its function. | ||||||
GW4869 | 6823-69-4 | sc-218578 sc-218578A | 5 mg 25 mg | $203.00 $611.00 | 24 | |
GW4869 is a non-competitive inhibitor of acid sphingomyelinase. It can inhibit GM2-AP by altering the lipid composition and potentially disrupting the lipid raft domains essential for GM2-AP's function in lipid transport. | ||||||
D-threo-PDMP | 109836-82-0 | sc-280659 | 10 mg | $808.00 | 1 | |
D-PDMP is a glucosylceramide synthase inhibitor. By inhibiting the synthesis of glycosphingolipids, it can inhibit GM2-AP by disrupting the lipid substrate pool necessary for its normal function in the cell. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). Perturbation of calcium homeostasis can inhibit GM2-AP by affecting its conformation or trafficking within the cell, which is calcium-dependent. | ||||||