glutathione S-transferase mu (GSTM) Inhibitors
GSTM, or glutathione S-transferase mu, is part of the GST family of enzymes that are key players in cellular detoxification processes. These enzymes catalyze the conjugation of glutathione, a critical antioxidant, to various substrates, including xenobiotics, drugs, and products of oxidative stress. GSTM enzymes are particularly important in the metabolism and detoxification of carcinogens, and their activity can influence the cellular response to oxidative stress and chemical insults. The expression of GSTM enzymes is often upregulated in response to oxidative stress and in various pathological conditions, including cancer. By facilitating the conjugation of glutathione to reactive intermediates, GSTM enzymes help in neutralizing toxins and protecting cells from damage.
Targeting GSTM for disruption or inhibition has been explored mainly in the context, as these enzymes can contribute to drug resistance and tumor survival. Inhibitors of GSTM are designed to increase the sensitivity of cancer cells to the detoxification of agents. However, the challenge in targeting GSTM lies in achieving specificity, as inhibiting these enzymes can also disrupt normal cellular detoxification processes, leading to increased susceptibility to oxidative stress and toxicity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid inhibits GSTM4 by binding to its active site, disrupting its enzymatic activity, and preventing the conjugation of glutathione with xenobiotics and endogenous compounds. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $60.00 $75.00 $125.00 $205.00 | 8 | |
Sulfasalazine inhibits GSTM4 through the formation of reactive metabolites that covalently modify the enzyme, leading to its inactivation and reduced detoxification capacity. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $67.00 $159.00 $312.00 $928.00 $1856.00 $6706.00 | 7 | |
This compound has been reported to inhibit GST. It has shown potential in stopping GST, particularly in cancer cells. | ||||||
Brusatol | 14907-98-3 | sc-507427 | 5 mg | $145.00 | 1 | |
A quassinoid extracted from Brucea javanica. Brusatol has been reported to inhibit GST activity, making it a subject of interest in cancer research. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
A naphthoquinone compound found in plants of the Plumbaginaceae family. Plumbagin can inhibit GST activity, which may enhance the cytotoxicity of chemotherapeutic agents. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol inhibits GSTM4 activity by binding to its active site, thereby blocking its ability to facilitate the detoxification of various xenobiotics. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Silybin inhibits GSTM4 by interfering with its active site, impairing its conjugation of glutathione with toxins and carcinogens. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol inhibits GSTM4 by disrupting its active site, which hinders its capacity to conjugate glutathione with harmful compounds. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate inhibits GSTM4 by binding to its active site, interfering with its role in the detoxification of electrophilic compounds. | ||||||