Glutathione reductase Inhibitors
Items 1 to 10 of 13 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 83583 | 91300-60-6 | sc-200314 sc-200314A | 5 mg 25 mg | $80.00 $225.00 | 3 | |
LY 83583 acts as a potent inhibitor of glutathione reductase, showcasing unique binding affinity that stabilizes the enzyme's inactive conformation. This compound alters the redox balance within cells by modulating the enzyme's catalytic efficiency, impacting the regeneration of reduced glutathione. Its specific interactions with key amino acid residues influence the enzyme's reaction kinetics, ultimately affecting cellular oxidative stress responses and metabolic pathways. | ||||||
Butein | 487-52-5 | sc-202510 sc-202510A | 5 mg 50 mg | $172.00 $306.00 | 8 | |
Butein functions as a modulator of glutathione reductase, exhibiting distinctive interactions with the enzyme's active site. Its presence can alter the enzyme's conformational dynamics, leading to changes in substrate accessibility and catalytic turnover rates. By influencing electron transfer mechanisms, Butein impacts the redox state of cellular environments, thereby affecting the overall balance of oxidative and reductive processes. This compound's unique structural features facilitate selective binding, enhancing its regulatory role in cellular metabolism. | ||||||
L-Buthionine sulfoximine | 83730-53-4 | sc-200824 sc-200824A sc-200824B sc-200824C | 500 mg 1 g 5 g 10 g | $280.00 $433.00 $1502.00 $2917.00 | 26 | |
Irreversible inhibition through blocking γ-glutamylcysteine synthetase, depleting cellular glutathione levels. | ||||||
Carmustine | 154-93-8 | sc-204671 sc-204671A sc-204671-CW | 25 mg 100 mg 25 mg | $105.00 $320.00 $128.00 | 1 | |
Carmustine acts as a potent inhibitor of glutathione reductase, engaging in specific interactions that disrupt the enzyme's catalytic efficiency. Its unique electrophilic properties allow it to form covalent bonds with critical thiol groups, altering the enzyme's active site and hindering substrate conversion. This modification can lead to a significant shift in redox homeostasis, impacting cellular oxidative stress responses and metabolic pathways. The compound's structural characteristics enable targeted modulation of enzyme activity, influencing overall cellular function. | ||||||
Lomustine | 13010-47-4 | sc-202697 | 50 mg | $99.00 | 2 | |
Lomustine exhibits a distinctive mechanism of action as a glutathione reductase inhibitor, characterized by its ability to form stable adducts with thiol residues within the enzyme. This interaction results in a conformational change that impairs the enzyme's function, effectively reducing its catalytic turnover. The compound's lipophilic nature enhances its membrane permeability, facilitating its access to intracellular targets and influencing redox balance and cellular signaling pathways. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $102.00 $408.00 $642.00 $1275.00 | 10 | |
Inhibits γ-glutamylcysteine synthetase, reducing glutathione synthesis and impacting glutathione reductase activity. | ||||||
2-Aminobenzimidazole | 934-32-7 | sc-254151 | 5 g | $31.00 | ||
Disrupts the glutathione reductase enzyme by interfering with its catalytic activity. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Inhibits glutathione reductase by covalently binding to its active site, preventing reduction of oxidized glutathione. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
Enhances glutathione levels by providing a precursor molecule (cysteine) for glutathione synthesis. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Induces oxidative stress and DNA damage, indirectly affecting glutathione reductase due to increased demand for reduced glutathione. | ||||||