Glut7 Activators
Glut7, a protein encoded by the SLC2A7 gene, can be activated by a range of chemical compounds. Retinoic acid, a naturally occurring chemical, acts as a ligand for a nuclear receptor, increasing the transcription of the SLC2A7 gene and enhancing Glut7 activity. Chrysin, a flavonoid compound, inhibits protein kinase C (PKC) activity, which normally suppresses Glut7 function, resulting in enhanced glucose transport. Resveratrol, found in grapes and berries, activates Glut7 by modulating the activity of AMP-activated protein kinase (AMPK), a pivotal cellular energy sensor. Berberine, a natural compound, stimulates the expression and translocation of Glut7 to the plasma membrane, facilitating glucose transport. Curcumin, a polyphenolic compound abundant in turmeric, activates Glut7 by inhibiting protein tyrosine phosphatase 1B (PTP1B), a negative regulator of Glut7. Quercetin, a flavonoid compound, increases Glut7 gene expression by inhibiting histone deacetylases (HDACs) that negatively regulate Glut7 expression.
Genistein, an isoflavone compound found in soybeans, inhibits protein kinase A (PKA) activity, leading to increased Glut7 activity. Epigallocatechin gallate (EGCG), abundant in green tea, activates Glut7 by modulating peroxisome proliferator-activated receptor gamma (PPARγ) activity, which regulates Glut7 expression. Daidzein, also found in soybeans, promotes Glut7 translocation to the plasma membrane and enhances AMPK activity. Ginsenoside Rb1 from ginseng activates Glut7 by modulating the mammalian target of rapamycin (mTOR) pathway, resulting in increased Glut7 expression and glucose transport. Luteolin, a flavonoid compound, inhibits glycogen synthase kinase-3β (GSK-3β), which negatively regulates Glut7 function. Kaempferol, found in fruits and vegetables, promotes Glut7 translocation to the plasma membrane and enhances AMPK activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a naturally occurring chemical that can activate Glut7. It acts as a ligand for a nuclear receptor, which then binds to specific DNA sequences and enhances the transcription of the SLC2A7 gene. This increased gene expression leads to higher levels of Glut7 protein, ultimately enhancing its activity in glucose transport. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes, berries, and other plants. It activates Glut7 by modulating the activity of AMP-activated protein kinase (AMPK), a key cellular energy sensor. Resveratrol activates AMPK, which in turn phosphorylates and activates Glut7, leading to increased glucose transport. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a natural isoquinoline alkaloid with multiple health benefits. It activates Glut7 by stimulating the expression and translocation of Glut7 to the plasma membrane. It also enhances AMPK activity, promoting Glut7 phosphorylation and subsequent activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound found in turmeric, can activate Glut7 by inhibiting the activity of protein tyrosine phosphatase 1B (PTP1B). PTP1B is a negative regulator of Glut7, and its inhibition by curcumin leads to increased Glut7 activity and glucose transport. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin compound abundant in green tea. It activates Glut7 by modulating the activity of peroxisome proliferator-activated receptor gamma (PPARγ). PPARγ is a transcription factor that regulates Glut7 expression. EGCG activates PPARγ, leading to increased Glut7 gene expression and subsequent enhancement of glucose transport. | ||||||
Daidzein | 486-66-8 | sc-24001 sc-24001A sc-24001B | 100 mg 500 mg 5 g | $28.00 $79.00 $165.00 | 32 | |
Daidzein is an isoflavone compound found in soybeans and other legumes. It activates Glut7 by promoting its translocation to the plasma membrane. Daidzein also enhances AMPK activity, resulting in the phosphorylation and activation of Glut7. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is a flavonoid compound found in various plants. It activates Glut7 by inhibiting the activity of glycogen synthase kinase-3β (GSK-3β). GSK-3β negatively regulates Glut7 function through phosphorylation, reducing its glucose transport activity. Luteolin inhibits GSK-3β, resulting in increased Glut7 activity. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol is a flavonoid compound present in many fruits and vegetables. It activates Glut7 by promoting its translocation to the plasma membrane. Kaempferol also enhances AMPK activity, leading to the phosphorylation and activation of Glut7. | ||||||