Glut2 Inhibitors
Glut2 inhibitors represent a class of chemical compounds designed to modulate the activity of the glucose transporter 2 (Glut2), a crucial player in cellular glucose transport and homeostasis. While direct Glut2 inhibitors are limited, several chemicals indirectly influence Glut2 by targeting key regulatory pathways involved in glucose metabolism. Phloretin, a competitive inhibitor of glucose transporters, including Glut2, directly interferes with glucose binding and transport across cell membranes. This inhibition disrupts Glut2-mediated glucose transport, impacting cellular glucose homeostasis. Similarly, compounds like Quercetin and WZB117 modulate AMP-activated protein kinase (AMPK) activity, indirectly influencing Glut2 function. AMPK activation inhibits glucose production and promotes glucose uptake, providing a unique avenue for exploring the regulatory mechanisms governing Glut2 activity.
The small molecule inhibitor STF-31 directly targets glucose transporters, affecting Glut2-mediated glucose uptake. Forskolin, Resveratrol, and BAY-876 offer indirect modulation by influencing AMPK activation, altering glucose metabolism, and affecting Glut2 function. AZD3965 and CP-91149 target mitochondrial pyruvate carrier and glucose transporter proteins, respectively, providing insights into the interconnected regulation of glucose metabolism and Glut2-mediated glucose transport. Furthermore, STF-118804 and WZB117 hydrochloride directly interfere with glucose transporters, impacting Glut2-mediated glucose uptake.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a competitive inhibitor of glucose transporters, including Glut2. It directly interferes with glucose binding and transport across cell membranes. By blocking glucose uptake, Phloretin can indirectly inhibit Glut2-mediated glucose transport, affecting cellular glucose homeostasis and metabolism. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 is a small molecule inhibitor that targets glucose transporters, including Glut2. It disrupts glucose transport across cell membranes by interfering with transporter function. This direct inhibition of glucose uptake can impact Glut2-mediated glucose transport, influencing cellular glucose utilization and metabolism. | ||||||
Genipin | 6902-77-8 | sc-203057 sc-203057A | 25 mg 100 mg | $82.00 $246.00 | 6 | |
Genipin is a natural compound with inhibitory effects on glucose transporters. It can indirectly modulate Glut2 by affecting AMP-activated protein kinase (AMPK) activity. Genipin activates AMPK, leading to the inhibition of glucose production and increased glucose uptake. This indirect modulation can impact Glut2-mediated glucose transport, providing insights into the complex regulation of glucose homeostasis and cellular metabolism. | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $187.00 | 3 | |
STF-31 is an inhibitor of glucose transporters that can impact Glut2 function. It interferes with glucose uptake by targeting glucose transporter proteins, including Glut2. This direct inhibition of glucose transport can affect Glut2-mediated glucose uptake, influencing cellular glucose utilization and metabolic processes. | ||||||
BAY-876 | 1799753-84-6 | sc-507539 | 5 mg | $240.00 | ||
BAY-876 is a selective inhibitor of the mitochondrial pyruvate carrier (MPC), impacting glucose metabolism and indirectly affecting Glut2. By inhibiting MPC, BAY-876 disrupts pyruvate transport into the mitochondria, influencing cellular metabolic pathways. This indirect modulation can alter Glut2-mediated glucose transport, providing insights into the interconnected regulation of mitochondrial metabolism and glucose homeostasis. | ||||||
CP-91149 | 186392-40-5 | sc-396026A sc-396026 sc-396026B sc-396026C sc-396026D | 5 mg 10 mg 25 mg 50 mg 100 mg | $163.00 $204.00 $398.00 $500.00 $714.00 | 1 | |
CP-91149 is a potent inhibitor of glucose transporter proteins, including Glut2. It directly interferes with glucose transport across cell membranes, impacting Glut2-mediated glucose uptake. This direct inhibition can influence cellular glucose utilization and metabolic processes, providing researchers with a tool to dissect the specific roles of Glut2 in glucose homeostasis and cellular metabolism. | ||||||