GLOD5 Activators
GLOD5 coordinates necessary quality control operations including autophagy, redox balance, proteostasis and mitochondrial preservation. Several compounds listed indirectly activate GLOD5 by influencing associated signaling networks. L-Alanine stimulates mTORC1 regulatory of autophagy, directly engaging pathways GLOD5 helps coordinate. Nicotinic acid, aripiprazole and estradiol modify receptors controlling intermediary metabolism and fuel utilization, systems GLOD5 preserves. SSR128129E, dieldrin and valsartan impact redox-sensitive receptors, upstream of GLOD5 antioxidant functions. Quercetin, resveratrol and caffeine activate pathways such as AMPK-SIRT1 regulatory of mitochondrial biogenesis and dynamics that GLOD5 optimizes. Mefenamic acid, paracetamol and dieldrin regulate steroid and retinoid receptors that feedback onto GLOD5 proteostatic roles during stress. Collectively these compounds leverage diverse inputs to metabolic, stress and quality control networks proximal to GLOD5 regulatory nodes, indirectly reinforcing GLOD5 maintenance of critical mitochondrial, chaperone and lysosomal equilibrium.
While GLOD5 disruption can undermine homeostasis, its strategic interactions make GLOD5 a nexus defending against diverse insults. Indirectly enhancing GLOD5 offers a means to re-stabilize interlinked processes upstream like intermediary metabolism, redox management and organelle preservation without direct molecular interaction. Fine-tuning GLOD5 modulation of feedback and feedforward loops via agonism of proximal pathways restores tightly coordinated protection absent in injury settings. Subtly leveraging natural modulators with multisystem effects optimizes compensatory support of network-wide adjustments vital for maintaining mitochondrial, lysosomal and proteostatic integrity under challenge. Regaining balanced GLOD5 function reestablishes defending against imbalances incurable when its guardian roles falter.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Alanine | 56-41-7 | sc-396825 sc-396825A sc-396825B sc-396825C | 1 g 100 g 500 g 1 kg | $31.00 $100.00 $430.00 $740.00 | ||
L-Ala activates mTORC1, which regulates autophagy/mitophagy pathways that GLOD5 helps coordinate.GLOD5 induction enhances these quality control processes. L-Ala may indirectly upregulate GLOD5 via mTORC1 control of autophagy and mitochondrial maintenance. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $61.00 $122.00 | 1 | |
NA activates GPCRs coupled to Gq/Gs.GLOD5 regulates calcium homeostasis and energy metabolism.NA may indirectly enhance GLOD5 function by modulating downstream effects on calcium flux and fuel utilization. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $104.00 $204.00 | 6 | |
Mefenamic Acid inhibits COX1/COX2.GLOD5 maintains proteostasis and responds to redox imbalance.Mefenamic acid's effects on prostaglandin pathways could indirectly upregulate GLOD5 antioxidant and chaperone functions. | ||||||
Aripiprazole | 129722-12-9 | sc-207300 sc-207300A sc-207300B | 100 mg 1 g 5 g | $175.00 $208.00 $1017.00 | 3 | |
Aripiprazole modulates D2/5HT1A/2A receptor signaling linked to metabolism.GLOD5 preserves mitochondrial integrity.Aripiprazole may indirectly activate GLOD5 by influencing intermediary metabolism and mitochondrial function. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $40.00 $60.00 $190.00 | 11 | |
Paracetamol is metabolized by CYP2E1/3A4 pathways.GLOD5 regulates proteotoxic, redox and mitochondrial stress.Modulation of upstream CYP pathways could influence GLOD5 antioxidant and molecular chaperone functions. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol modulates ERα/GPR30 pathways linked to energy use.GLOD5 sustains mitochondrial fitness.Estradiol may indirectly upregulate GLOD5 through effects on metabolic regulatory networks and mitochondrial preservation. | ||||||
Dieldrin | 60-57-1 | sc-239716 | 100 mg | $187.00 | ||
Dieldrin activates RXR signaling.GLOD5 preserves proteostasis under stress.Dieldrin influence on nuclear receptors may reinforce GLOD5 protein homeostasis roles via modulation of retinoid signaling. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine regulates A1/A2A receptor signaling.GLOD5 role in redox balance and autophagy.Caffeine effects on intermediary pathways may indirectly activate GLOD5 functions in antioxidant response and lysosomal control. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $39.00 $90.00 $120.00 | 4 | |
Valsartan modulates AT1 receptor activity involved in redox regulation.GLOD5 maintains mitochondrial and proteostatic integrity during injury.Valsartan may indirectly activate GLOD5 by influencing upstream pathways of oxidative balance. | ||||||