GIP Inhibitors
The chemical class of GIP inhibitors predominantly consists of compounds that indirectly affect GIP by targeting various aspects of glucose regulation, insulin secretion, and gastrointestinal function. These inhibitors primarily influence the pathways and processes associated with GIP's role in metabolic regulation rather than directly inhibiting the hormone itself.
Compounds such as Proglumide, Octreotide, and GLP-1 analogs affect gastrointestinal hormone secretion and action, which can indirectly impact GIP levels and function. Proglumide and Octreotide, targeting cholecystokinin and somatostatin receptors, respectively, might alter GIP secretion in the gut. GLP-1 analogs, commonly used in diabetes management, could modulate the incretin effect, of which GIP is a part. Additionally, compounds like Nateglinide, Repaglinide, Acarbose, Voglibose, Metformin, and Pioglitazone can influence GIP indirectly through their effects on glucose absorption, insulin secretion, and insulin sensitivity. DPP-4 inhibitors, such as Sitagliptin, increase incretin levels and could thereby modulate the activity of GIP.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Exendin-4 | 141758-74-9 | sc-474611 sc-474611A | 500 µg 1 mg | $143.00 $194.00 | 1 | |
Exendin-4, a GLP-1 agonist, might influence GIP secretion or action as part of its regulatory effects on glucose levels. | ||||||
Nateglinide | 105816-04-4 | sc-394067 sc-394067A | 10 mg 25 mg | $188.00 $260.00 | ||
Nateglinide stimulates insulin secretion, which could indirectly modulate GIP activity in glucose regulation. | ||||||
Repaglinide | 135062-02-1 | sc-219959 sc-219959A sc-219959B | 100 mg 250 mg 1 g | $215.00 $414.00 $1331.00 | 3 | |
Repaglinide, an insulin secretagogue, may have indirect effects on GIP secretion or function. | ||||||
Acarbose | 56180-94-0 | sc-203492 sc-203492A | 1 g 5 g | $222.00 $593.00 | 1 | |
Acarbose, an alpha-glucosidase inhibitor, might influence GIP levels by altering carbohydrate absorption. | ||||||
Voglibose | 83480-29-9 | sc-204384 sc-204384A | 10 mg 50 mg | $194.00 $668.00 | ||
Voglibose, another alpha-glucosidase inhibitor, could indirectly affect GIP activity through its effects on digestion. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin can indirectly influence GIP secretion or action. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a thiazolidinedione, might indirectly affect GIP through its insulin-sensitizing actions. | ||||||
Sitagliptin | 486460-32-6 | sc-482298 sc-482298A sc-482298B | 25 mg 100 mg 1 g | $209.00 $464.00 $719.00 | 10 | |
Sitagliptin, a DPP-4 inhibitor, could indirectly affect GIP by modulating incretin hormone levels. | ||||||