Molecular structure of Voglibose, CAS Number: 83480-29-9
Voglibose (CAS 83480-29-9)
Alternate Names:
Basen; Glustat; Vocarb
Application:
Voglibose is an α-glucosidase inhibitor that increases glucagon-like peptide 1 secretion
CAS Number:
83480-29-9
Purity:
≥99%
Molecular Weight:
267.28
Molecular Formula:
C10H21NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Voglibose is orally active Maltase-glucoamylase (alpha-glucosidase) inhibitor (IC50 values are 3.9 and 6.4 nM at sucrase and maltase respectively). It increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice. Voglibose reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Additionally, voglibose exhibits antidiabetic and antiobesity activity in vivo.
Voglibose (CAS 83480-29-9) References
- Role of voglibose in the treatment of prediabetes in Indian population: a cross-speciality survey. | Dewda, PR. and Agrawal, S. 2013. J Clin Diagn Res. 7: 2258-60. PMID: 24298491
- Voglibose: an alpha glucosidase inhibitor. | Dabhi, AS., et al. 2013. J Clin Diagn Res. 7: 3023-7. PMID: 24551718
- Voglibose-inspired synthesis of new potent α-glucosidase inhibitors N-1,3-dihydroxypropylaminocyclitols. | Worawalai, W., et al. 2016. Carbohydr Res. 429: 155-62. PMID: 27140506
- Voglibose-mediated alterations in neurometabolomic profiles in the hypothalamus of high-fat diet-fed mice. | Yang, SJ., et al. 2019. Nutr Neurosci. 22: 760-767. PMID: 29495953
- Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice. | Kato, J., et al. 2020. Int J Mol Sci. 21: PMID: 32210144
- Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo. | Nepal, MR., et al. 2020. Diabetes Metab J. 44: 908-918. PMID: 32431100
- The effect of voglibose on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. | Nowrouzi-Sohrabi, P., et al. 2020. Pharmacol Res. 159: 104988. PMID: 32504833
- Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies. | Shah, P., et al. 2020. Curr Gene Ther. 20: 223-235. PMID: 33054705
- Spectroscopic and theoretical evidences for the surface binding of voglibose drug with DNA. | Durga Priyadharshini, R., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 271: 120888. PMID: 35063822
- The effects of the voglibose on non-alcoholic fatty liver disease in mice model. | Bae, J., et al. 2022. Sci Rep. 12: 13595. PMID: 35948569
- Case of pneumatosis cystoides intestinalis with intra-abdominal free air developed during treatment with voglibose. | Hisanaga, E., et al. 2022. JGH Open. 6: 643-646. PMID: 36091325
- Voglibose and saxagliptin ameliorate the post-surgical stress and cognitive dysfunction in chronic anaesthesia exposed diabetic MCAo induced ischemic rats. | Chavda, V. and Patel, S. 2022. IBRO Neurosci Rep. 13: 426-435. PMID: 36386599
- Voglibose Regulates the Secretion of GLP-1 Accompanied by Amelioration of Ileal Inflammatory Damage and Endoplasmic Reticulum Stress in Diabetic KKAy Mice. | Fu, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36555580
Inhibitor of:
α-Amylase, from Bacillus amyloliquefaciens, α-Glucosidase, AGL, AI464131, AL-1, Amylase 1, Amylase 1a, Amylase 1b, Amylase 1c, Amylase 2, Amylase 2-2, Amylase 2A, Amylase 2a2, Amylase 2a3, Amylase 2a4, Amylase 2B, Amyloglucosidase, Enzyme, FUCA1, GANC, GIP, Glucose Oxidase, Glucosidase I, GnT-IVB, LCT, Maltase-glucoamylase, MAN1C1, MANEA, MANEAL, Pancreatic Icosapeptide, PGM 2L1, Sucrase-Isomaltase, and Trehalase.Activator of:
α-Glucosidase, ALG1L, ALG1L2, Amylase 2a3, Amyloglucosidase, and G6PT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Voglibose, 10 mg | sc-204384 | 10 mg | $194.00 | |||
Voglibose, 50 mg | sc-204384A | 50 mg | $668.00 |