GGA3 Inhibitors
GGA3 inhibitors represent a class of small molecules specifically designed to interfere with the function of Golgi-localized, gamma adaptin ear-containing, ARF-binding proteins (GGAs), with a particular focus on GGA3 isoform. GGAs are essential components of cellular vesicular trafficking machinery, playing a crucial role in the sorting and transport of cargo proteins between the trans-Golgi network (TGN) and endosomes. GGA3, one of the three GGA isoforms found in humans, functions as an adaptor protein that facilitates the assembly of clathrin-coated vesicles at the TGN, allowing the selective transport of cargo proteins from the Golgi apparatus to endosomes or lysosomes. Small molecules classified as GGA3 inhibitors are meticulously designed to disrupt the interactions between GGA3 and its associated proteins or regulatory factors, thereby modulating the formation of clathrin-coated vesicles and affecting intracellular protein trafficking pathways.
These inhibitors often target specific binding sites or regulatory domains within GGA3, hindering its ability to recognize cargo proteins or interact with essential components of the vesicular transport machinery. By interfering with these protein-protein interactions, GGA3 inhibitors perturb the normal progression of vesicle formation and cargo sorting. Consequently, this disruption leads to alterations in the distribution and localization of cellular proteins, impacting various cellular processes that rely on precise protein trafficking. The development and study of GGA3 inhibitors not only provide valuable insights into the intricate mechanisms of intracellular transport but also offer potential tools for researchers to dissect the complex pathways involved in cellular homeostasis, aiding in the elucidation of fundamental biological processes within the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits GGA3 by disrupting the Golgi apparatus and interfering with vesicle trafficking. It prevents the formation of COPI-coated vesicles, hindering the transport of proteins from the endoplasmic reticulum to the Golgi. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
Golgicide A selectively inhibits GGA3 by disrupting the Golgi structure and inhibiting the retrograde transport of proteins. It does so by targeting the ADP-ribosylation factor 1 (ARF1), a key regulator of vesicular trafficking. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin inhibits GGA3 by disrupting clathrin-mediated endocytosis. It interferes with the interaction between GGA3 and clathrin, preventing the formation of clathrin-coated vesicles and inhibiting protein sorting. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin inhibits GGA3 by disrupting clathrin-mediated endocytosis and impairing vesicular trafficking. It interferes with GGA3 function, leading to altered protein sorting and impaired transport between cellular compartments. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits GGA3 by disrupting clathrin-mediated endocytosis. It interferes with the interaction between clathrin and its adaptors, preventing the formation of clathrin-coated vesicles and inhibiting protein internalization. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
N-ethylmaleimide inhibits GGA3 by disrupting vesicle fusion processes. It modifies cysteine residues on SNARE proteins, essential for membrane fusion events, leading to the inhibition of vesicle trafficking between cellular compartments. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits GGA3 by disrupting dynamin-mediated vesicle scission. It interferes with the GTPase activity of dynamin, preventing the pinching off of clathrin-coated vesicles and inhibiting the internalization of plasma membrane proteins. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine inhibits GGA3 by disrupting clathrin-mediated endocytosis. It interferes with the assembly of clathrin-coated vesicles by preventing the recruitment of clathrin and its adaptors, leading to inhibition of protein internalization. | ||||||