GDF-11 Inhibitors
GDF-11 inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of GDF-11, which stands for Growth Differentiation Factor 11. GDF-11 is a member of the transforming growth factor-beta (TGF-β) superfamily, a group of proteins involved in regulating various cellular processes, including cell growth, differentiation, and development. It is primarily known for its role in embryonic development and tissue regeneration. Inhibition of GDF-11 activity using specific inhibitors is an important strategy employed in scientific research to dissect the molecular mechanisms underlying its function and its impact on cellular processes.
These inhibitors can take the form of small molecules or peptides that are carefully designed to interfere with the binding of GDF-11 to its receptors or downstream signaling pathways. By inhibiting GDF-11, researchers can gain valuable insights into its role in tissue development and regeneration, as well as its involvement in maintaining tissue homeostasis in adult organisms. Furthermore, understanding the regulation of GDF-11 is critical in unraveling the complex interplay of signaling pathways that govern tissue growth and repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits the activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7, which are part of the TGF-β superfamily signaling pathways, potentially influencing GDF-11 signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
Acts as a potent ATP-competitive inhibitor of TGF-β type I receptor ALK5 kinase, possibly affecting downstream signaling of GDF-11. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
Selectively inhibits ALK5, ALK4, and ALK7, which could alter the TGF-β signaling pathway, thereby affecting GDF-11 related processes. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
A selective TGF-βRI (ALK5) kinase inhibitor, potentially modulating TGF-β superfamily signals including GDF-11. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
A selective inhibitor of TGF-β receptor I kinase, potentially influencing GDF-11 signaling by altering TGF-β pathway activity. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Selectively inhibits ALK5, potentially affecting GDF-11 activity by altering TGF-β signaling. | ||||||
Pirfenidone | 53179-13-8 | sc-203663 sc-203663A | 10 mg 50 mg | $102.00 $416.00 | 6 | |
While not a direct inhibitor of the TGF-β pathway, it has been shown to modulate this pathway, potentially affecting GDF-11 signaling. | ||||||
Tranilast | 53902-12-8 | sc-200389 sc-200389A sc-200389B sc-200389C | 10 mg 50 mg 1 g 5 g | $31.00 $103.00 $283.00 $978.00 | 2 | |
Modulates TGF-β activity and may indirectly influence GDF-11 signaling. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Inhibits BMP signaling by targeting ALK2, ALK3, and ALK6, which are in the TGF-β superfamily, potentially affecting GDF-11. | ||||||