GCC1 Activators
GCC1 is a critical regulator of mitochondrial dynamics, calcium signaling, and cytoskeletal remodeling. Several GPRC and nuclear receptor agonists presented can enhance GCC1 activity indirectly through their effects on signaling networks GCC1 interfaces with. LPA, S1P, ATP and other lysolipids signal through GPCRs coupled to Rho GTPases like RhoA and RhoG that GCC1 positively modulates. This enhances cytoskeletal dynamics central to GCC1 functions in cell migration, division and intracellular transport.
Nuclear receptor ligands including thyroid hormone, retinoic acid and cannabidiol regulate mitochondrial metabolism, biogenesis and quality control pathways downstream of GCC1. By fine-tuning metabolic and mitochondrial signaling networks, these compounds can reinforce GCC1 control of mitochondrial fusion and calcium cycling. Receptor ligands for arachidonic acid and eicosapentanoic acid metabolites activate GPCRs involved in Rho GTPase regulation of actin reorganization critical for processes like migration GCC1 facilitates. Uroguanylin stimulates solute transport and mitochondrial functioning through pathways converging on GCC1 regulatory targets. Collectively, these compounds provide diverse modulatory inputs that reinforce specific biological functions GCC1 orchestrates in metabolic regulation, cytoskeletal dynamics and mitochondrial quality control.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. This elevation of cAMP can enhance the PKA pathway which, in turn, can lead to the phosphorylation of GCAP3, thereby enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, increasing their levels in cells. Elevated cGMP can bind to GCAP3, altering its conformation and enhancing its activity. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain binds to the Na+/K+-ATPase pump, which leads to an increase in intracellular calcium concentrations. GCAP3, being sensitive to calcium levels, may have enhanced activity under such conditions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the SERCA pump, leading to an increase in intracellular calcium. Elevated calcium can activate GCAP3 by inducing conformational changes that increase its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a calcium ionophore, increasing intracellular calcium concentration. As GCAP3 is a calcium-binding protein, the increased calcium availability can enhance its activation and function. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase type 5, which increases cGMP levels in the cell. GCAP3, which can bind cGMP, can be activated by higher cGMP levels leading to enhanced activity. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine blocks L-type calcium channels, which can lead to an altered calcium homeostasis within the cell. This change can influence the activation state of calcium-sensitive proteins like GCAP3. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), which can lead to changes in cytoskeletal dynamics affecting intracellular signaling pathways that could result in the activation of GCAP3. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a phosphodiesterase (PDE) inhibitor, specifically inhibiting PDE1. This inhibition can increase cAMP and cGMP levels, potentially enhancing the activation of GCAP3 through cGMP binding. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine inhibits calcium channels, thereby influencing intracellular calcium levels. The modulation of calcium levels can lead to the activation of calcium-binding proteins like GCAP3. | ||||||