GBP6 Activators
Chemical activators of GBP6 encompass a spectrum of compounds that can potentially increase the expression or activity of GBP6 through diverse mechanisms involving modulation of signaling pathways and transcriptional regulation. Compounds such as anisomycin and (R)-roscovitine influence the JNK and CDK-related pathways, respectively, potentially leading to increased expression of stress response proteins including GBP6. Lithium chloride, by inhibiting GSK-3, could activate the Wnt signaling pathway, resulting in transcriptional activation of genes including possibly those coding for GTPases. L-Ascorbic acid, as an antioxidant, can have an impact on the cellular redox state and influence the activation of proteins involved in the response to oxidative stress, such as GBP6.
Additionally, compounds that modulate cyclic AMP levels, like dibutyryl-cAMP and isoproterenol, act through the PKA pathway and can initiate a cascade that might result in GBP6 activation. The PPARγ agonist ciglitazone could lead to changes in gene expression profiles, potentially increasing levels of proteins involved in immune responses. AICAR, as an AMPK activator, might promote an energy-conserving state in the cell, potentially enhancing the expression or activity of GBP6. Hormonal modulation by compounds such as β-estradiol can also result in the upregulation of genes in the immune function context. Compounds like tauroursodeoxycholic acid serve as chemical chaperones and may enhance cellular capacity to cope with stress, which might include upregulation of GBP6. Lastly, Eicosapentaenoic acid (EPA) can interact with inflammatory pathways, possibly leading to an increase in GBP6 expression or activity in response to such signals.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin acts as a JNK activator. JNK activation can lead to transcription factor activation, such as c-Jun, which may upregulate genes including those coding for GTPases like GBP6. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
A cyclin-dependent kinase inhibitor that by inhibiting certain CDKs, could lead to cell cycle arrest and upregulation of stress response proteins including GTPases, potentially increasing GBP6 expression or activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can activate the Wnt signaling pathway indirectly by inhibiting GSK-3, leading to increased transcription of Wnt-responsive genes, which may include genes such as GBP6. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Similar to Roscovitine, this is a CDK inhibitor that may indirectly lead to increased expression of protective cellular response proteins, including potential upregulation of GBP6. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
it can modulate cellular redox status, which can influence various signaling pathways, potentially leading to activation of proteins involved in the cellular response to oxidative stress, including GBP6. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that can activate PKA, potentially leading to the activation of downstream genes that may include those coding for GTPases such as GBP6. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
A beta-adrenergic agonist that can elevate cAMP and activate PKA, potentially influencing pathways that could lead to the activation of GBP6. | ||||||
Ciglitazone | 74772-77-3 | sc-200902 sc-200902A | 5 mg 25 mg | $102.00 $420.00 | 10 | |
A PPARγ agonist which may enhance the expression of genes involved in energy balance and metabolism, and could indirectly upregulate proteins like GBP6 associated with immune responses. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMPK, which can upregulate cellular energy metabolism. Activation of AMPK could lead to a cellular state that increases the expression or activity of GBP6 as part of the cell's adaptive response. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Hormone that can modulate gene expression through estrogen receptors, potentially increasing the expression of GBP6 as part of the regulation of immune function and protein synthesis. | ||||||