Gatm Activators
Glycine amidinotransferase (GATM) Activators are a group of chemical compounds that directly and indirectly enhance the functional activity of GATM through various biochemical pathways. As the enzyme responsible for the first step in creatine biosynthesis, GATM's activity is directly augmented by the availability of its substrates, arginine and glycine. Elevated levels of these amino acids enhance GATM activity by providing the necessary components for the catalytic conversion to guanidinoacetate. Moreover, ornithine, by modulating the urea cycle, indirectly preserves arginine levels, thus promoting GATM function. The activity of GATM is further supported by the transmethylation pathway, where methionine and S-Adenosylmethionine (SAMe) play crucial roles. SAMe, as the principal methyl donor, and methionine, as a participant in the same cycle, indirectly stimulate GATM by ensuring the downstream usage of guanidinoacetate, which in turn necessitates the continuous operation of GATM.
Additionally, compounds like choline and betainecontribute to methyl group donations, indirectly facilitating the activity of GATM by influencing the methionine cycle to enhance the utilization of guanidinoacetate. Folic acid and Vitamin B12 are vital for one-carbon metabolism and the remethylation of homocysteine to methionine, respectively, indirectly fostering GATM activity by maintaining the supply chain of methyl groups necessary for creatine synthesis. Trace elements such as Zinc and Magnesium are essential for GATM's structural and functional integrity; Zinc serves as a cofactor required for the enzymatic action, and Magnesium stabilizes the enzyme and assists in its catalytic process. Interestingly, creatine itself, typically a negative feedback inhibitor of GATM, can under certain conditions devoid of creatine, enhance GATM activity by removing the feedback inhibition, thus allowing an upregulation of GATM's role in creatine biosynthesis to meet cellular demand. Collectively, these GATM activators, through their specific roles in metabolic pathways and as enzyme cofactors, ensure the optimal functioning of GATM in creatine production, highlighting the interconnected nature of metabolic regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
Arginine is a substrate for GATM, which catalyzes the conversion of arginine and glycine to guanidinoacetate, a precursor to creatine. The presence of arginine directly enhances GATM activity by providing the necessary substrate for its enzymatic action. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine serves as another substrate for GATM in the biosynthesis of guanidinoacetate. Adequate levels of glycine can enhance the functional activity of GATM by ensuring continuous substrate availability for the reaction it catalyzes. | ||||||
DL-Methionine | 59-51-8 | sc-397777 | 100 g | $45.00 | ||
Methionine contributes to the transmethylation pathway, which includes the conversion of guanidinoacetate to creatine. By participating in the methylation cycle, methionine indirectly supports GATM activity by ensuring the downstream utilization of its product. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe is the principal methyl donor in the transmethylation pathway and is essential for the methylation of guanidinoacetate to form creatine. By providing methyl groups, SAMe indirectly enhances GATM activity by driving the consumption of its enzymatic product. | ||||||
Choline base solution | 123-41-1 | sc-239545 | 100 ml | $79.00 | ||
Choline is involved in the metabolism of methionine and indirectly influences the transmethylation pathway. By contributing to the pool of methyl donors, choline can indirectly enhance GATM activity. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine acts as a methyl donor in the methionine cycle and can indirectly enhance GATM activity by facilitating the utilization of guanidinoacetate, promoting continuous enzymatic activity of GATM. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid is critical in one-carbon metabolism and indirectly supports GATM activity by contributing to the generation of S-Adenosylmethionine (SAMe), which is necessary for the methylation of guanidinoacetate. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is a cofactor in the methionine cycle and is essential for the remethylation of homocysteine to methionine. By sustaining the methionine cycle, Vitamin B12 indirectly enhances GATM activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for GATM and is essential for its structural integrity and catalytic activity. Adequate zinc levels are necessary to maintain the functional activity of GATM. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $28.00 $79.00 | 2 | |
Creatine serves as a negative feedback inhibitor of GATM under normal physiological conditions. However, in the absence of creatine, the lack of feedback inhibition can enhance GATM activity by upregulating its function to compensate for the reduced creatine levels. | ||||||