GAPDH-2 Activators
GAPDH-2 Activators play a vital role in enhancing the functionality of GAPDH-2, particularly in the context of glycolysis and energy metabolism in spermatozoa. Direct activators like NAD+ are crucial for the enzymatic activity of GAPDH-2, facilitating the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate in the glycolytic pathway. Indirect activators, such as Fructose-1,6-bisphosphate, ensure the continuation of the glycolysis pathway, supporting the enzymatic role of GAPDH-2 in later stages. Similarly, Pioglitazone and Metformin, by improving insulin sensitivity and glucose uptake, increase the availability of glucose, indirectly enhancing the glycolytic activity of GAPDH-2. Insulin also plays a significant role in promoting glucose uptake in cells, indirectly supporting GAPDH-2's glycolytic function.
In addition to these, Berberine and Rosiglitazone, by improving glucose homeostasis, indirectly enhance the activity of GAPDH-2 in glycolysis, critical for energy production in sperm cells. Caffeine, with its metabolic effects, potentially increases glucose utilization, thereby supporting GAPDH-2 activity. Epigallocatechin gallate (EGCG) and Chromium Picolinate, through their roles in modulating glucose metabolism, contribute to the increased availability of glucose for glycolysis, indirectly benefiting GAPDH-2's function. L-Carnitine, by facilitating fatty acid transport and metabolism, indirectly supports cellular energy production, including glycolysis, where GAPDH-2 is involved. Lastly, Alpha-Lipoic Acid enhances GAPDH-2 activity by improving insulin sensitivity and glucose utilization, crucial for the efficient functioning of glycolysis and subsequent energy production in spermatozoa. Together, these activators illustrate the intricate interplay between metabolic pathways and the critical role of GAPDH-2 in energy metabolism, particularly in the unique context of sperm function and vitality.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ (Nicotinamide adenine dinucleotide), as an essential cofactor, directly enhances GAPDH-2 activity by participating in its enzymatic reaction. GAPDH-2, being a glycolytic enzyme, requires NAD+ for the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate, thus playing a crucial role in the glycolysis pathway, particularly in spermatozoa where GAPDH-2 is prominently active. | ||||||
D-Fructose 1,6-bisphosphate sodium salt | 488-69-7 | sc-484714 | 50 g | $304.00 | ||
Fructose-1,6-bisphosphate, a glycolytic intermediate, indirectly enhances GAPDH-2 activity by contributing to the glycolysis pathway. As GAPDH-2 is involved in later stages of glycolysis, the presence of fructose-1,6-bisphosphate ensures the continuation of the pathway, indirectly supporting the enzymatic activity of GAPDH-2 in sperm energy metabolism. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, indirectly enhances GAPDH-2 activity by modulating glucose metabolism. By improving insulin sensitivity and enhancing peripheral glucose uptake, it increases the availability of glucose, the substrate for glycolysis, thereby indirectly supporting GAPDH-2 activity in glycolysis, particularly in sperm cells. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin, an antidiabetic agent in research, indirectly enhances GAPDH-2 activity by improving insulin sensitivity and glucose uptake. This increased availability of glucose, the primary substrate for glycolysis, indirectly supports GAPDH-2's role in this pathway, especially relevant in spermatozoa for energy production. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin, a hormone regulating glucose levels, indirectly enhances GAPDH-2 activity by promoting glucose uptake in cells. This increase in available glucose indirectly supports the glycolytic activity of GAPDH-2, particularly in spermatozoa, where it plays a vital role in energy metabolism through glycolysis. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine, an alkaloid with anti-hyperglycemic properties, indirectly enhances GAPDH-2 activity by improving glucose homeostasis. This effect indirectly supports glycolysis and the activity of GAPDH-2 by ensuring the availability of glucose, particularly important in sperm cells for energy production. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a PPAR-gamma agonist, indirectly enhances GAPDH-2 activity by improving insulin sensitivity and glucose uptake. This increased glucose availability indirectly supports the activity of GAPDH-2 in the glycolysis pathway, essential for energy metabolism in spermatozoa. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a stimulant, indirectly enhances GAPDH-2 activity by influencing metabolic processes. By increasing metabolic rate and potentially glucose utilization, caffeine indirectly supports GAPDH-2 activity in glycolysis, particularly in sperm cells, where GAPDH-2 is crucial for energy production. | ||||||
Chromium Picolinate | 14639-25-9 | sc-204685 sc-204685A | 5 g 25 g | $214.00 $667.00 | 1 | |
Chromium Picolinate, a dietary supplement, indirectly enhances GAPDH-2 activity by improving insulin sensitivity and glucose uptake. Increased glucose availability supports glycolysis, thereby indirectly supporting the activity of GAPDH-2, particularly in energy metabolism in sperm cells. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine, a dietary supplement, indirectly enhances GAPDH-2 activity by facilitating fatty acid transport and metabolism. This indirectly supports cellular energy production, including glycolysis, thereby supporting GAPDH-2 activity, particularly in sperm cells where it plays a key role in energy metabolism. | ||||||