γA-crystallin Activators
The chemical class known as γA-crystallin (CRYGA) Activators encompasses a diverse array of compounds that can play a role in the stabilization and maintenance of γA-crystallin's structural integrity and function within the ocular lens. These activators include small organic molecules, vitamins, and other naturally occurring compounds that can interact with γA-crystallin or its surrounding environment in the lens. Their primary mode of action is based on their capacity to either prevent the aggregation of γA-crystallin, which is essential for maintaining lens transparency, or to protect it from oxidative stress, which can lead to protein cross-linking and opacity. This group of chemicals can enhance the solubility of γA-crystallin, ensuring its proper folding and assembly within the lens fibers, which is critical for the refractive properties required for clear vision.
The activators can also serve as antioxidants, providing a shield against the oxidative damage that the lens cells are particularly susceptible to due to their long lifespan and high exposure to light. As antioxidants, these compounds can neutralize free radicals and reduce oxidative stress, conditions known to affect lens proteins. Some of the chemicals in this class are known for their ability to penetrate cellular membranes, which can be advantageous in reaching intracellular targets like γA-crystallin. Furthermore, some activators work by participating in the post-translational modification of lens proteins, assisting in the proper folding and structural configuration that is essential for γA-crystallin's role within the lens. By maintaining the clarity and solubility of γA-crystallin, these activators play a crucial role in the preservation of lens transparency and the prevention of protein aggregation, contributing to the overall homeostasis within the ocular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lanosterol | 79-63-0 | sc-215229 sc-215229A | 1 mg 5 mg | $103.00 $343.00 | 2 | |
Lanosterol has been shown to reduce lens opacity by dissolving aggregation-prone proteins in the lens, which could possibly activate CRYGA by maintaining it in its soluble, functional state. | ||||||
Geranylgeraniol | 24034-73-9 | sc-200858 sc-200858A | 20 mg 100 mg | $159.00 $465.00 | 14 | |
As a post-translational modification substrate, geranylgeraniol can facilitate proper folding and function of lens proteins through isoprenylation, which could possibly activate CRYGA stability. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
DMSO is known to penetrate biological membranes and can act as a cryoprotectant, potentially preserving the structure of lens proteins including CRYGA, which could possibly activate its stability during stress. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium is an essential trace element that contributes to antioxidant defense systems, potentially protecting CRYGA from oxidative damage, which could possibly activate its stability and function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is an essential mineral for the eye, playing a role in enzyme function and protein structure, possibly contributing to the stability of lens proteins such as CRYGA, which could possibly activate its structural integrity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Vitamin C is an antioxidant that can reduce oxidative stress in the lens, possibly preventing the aggregation of proteins like CRYGA, which could possibly activate its clarity and function. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that can mitigate oxidative stress, potentially preserving the functional state of CRYGA, which could possibly activate its solubility. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a polyphenol found in green tea, has antioxidant properties that can protect lens proteins from oxidative damage, potentially maintaining CRYGA's solubility and function, which could possibly activate its protective mechanisms. | ||||||
Carnosine | 305-84-0 | sc-202521A sc-202521 | 100 mg 1 g | $20.00 $43.00 | 1 | |
N-acetylcarnosine is a dipeptide that can have antioxidant effects in the lens, possibly supporting the maintenance of CRYGA structure and preventing aggregation, which could possibly activate its optical properties. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a compound from turmeric with anti-inflammatory and antioxidant effects, which may protect crystallins like CRYGA from oxidative stress, which could possibly activate its structural preservation. | ||||||