γ2-COP Activators
The chemical class of γ2-COP activators encompasses a diverse array of compounds primarily influencing intracellular trafficking and membrane dynamics. These chemicals interact with various components of the cell's cytoskeleton, vesicular transport systems, and membrane formation processes, which indirectly affect the function of γ2-COP. For example, compounds like Brefeldin A and Golgicide A target the formation and maintenance of the Golgi apparatus, indirectly modulating γ2-COP activity due to its critical role in COPI coatomer complex function and vesicular transport. Similarly, agents like Nocodazole and Cytochalasin D, which disrupt microtubules and actin filaments respectively, can indirectly influence γ2-COP by altering the overall dynamics of vesicular trafficking and cellular transport mechanisms.
Moreover, compounds like Forskolin, Monensin, and Dynasore modify intracellular signaling, pH, and ion concentration, or inhibit specific proteins like dynamin, which are vital for vesicle formation and transport. Such modifications can lead to compensatory changes in γ2-COP function as the cell attempts to maintain its intracellular transport and membrane trafficking homeostasis. Additionally, SecinH3, ML141, Latrunculin A, Jasplakinolide, and Wiskostatin modulate GTPase signaling and actin dynamics, further impacting vesicular transport processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
A microtubule-depolymerizing agent that affects intracellular transport and the distribution of the Golgi apparatus. By disrupting microtubules, nocodazole can indirectly influence γ2-COP function by altering the dynamics of vesicular trafficking. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can influence various cellular processes, including vesicular trafficking, potentially impacting γ2-COP activity indirectly. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
An ionophore that alters intracellular pH and ion concentrations, affecting vesicle formation and trafficking. Through these alterations, monensin can indirectly modulate γ2-COP activity. | ||||||
Cytochalasin C | 22144-76-9 | sc-202118 sc-202118A | 1 mg 5 mg | $122.00 $512.00 | 1 | |
Inhibits actin polymerization, affecting cell shape and motility. This alteration in cytoskeletal dynamics can indirectly influence γ2-COP function in vesicular trafficking. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A small molecule that inhibits dynamin, a GTPase involved in vesicle scission. By modulating dynamin activity, dynasore can indirectly affect γ2-COP function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
A Cdc42 inhibitor, affecting actin dynamics. Alterations in actin cytoskeleton can influence vesicular trafficking, potentially modulating γ2-COP activity. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin filaments, impacting cellular processes including vesicle movement. This could influence γ2-COP function indirectly. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments, affecting cell shape and vesicle trafficking. Indirectly modulates γ2-COP by influencing the cytoskeletal dynamics. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits N-WASP, impacting actin polymerization and vesicular trafficking. This might indirectly influence γ2-COP function. | ||||||