GAL3ST2 Activators
GAL3ST2 activators predominantly focus on altering existing metabolic and signaling pathways to indirectly influence the protein's activity. The first class of activators target the sphingolipid metabolism, such as Sphingosine and D-erythro-Sphingosine-1-phosphate, by augmenting ceramide levels or related signaling, consequently affecting GAL3ST2. Another prominent class, including agents like PMA and EGF, exert their effects through kinase-mediated pathways, including PKC and MAPK. Activation of these kinases can cascade down to metabolic pathways in which GAL3ST2 is a participant, leading to its activation.
The second class relies on cellular messengers or other forms of indirect modification. For instance, Forskolin acts by increasing intracellular cAMP levels, and Insulin activates PI3K-Akt signaling, both of which can result in the modification of GAL3ST2 activity. These activators offer a diverse yet focused approach to modulate GAL3ST2 through well-established cellular pathways. By understanding the specific biochemical interactions, one can grasp how these chemicals effectively act as activators for GAL3ST2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine is a key component of sphingolipid metabolism. It can elevate ceramide levels, subsequently increasing GAL3ST2 activity through ceramide signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which is upstream of various metabolic pathways including sphingolipid metabolism. Activation of PKC can thus lead to increased GAL3ST2 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
A bioactive lipid mediator in sphingolipid metabolism, indirectly enhancing GAL3ST2 activity via ceramide signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates intracellular cAMP, which is thought to modulate various metabolic pathways that indirectly lead to increased GAL3ST2 activity. | ||||||
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Sorbitol impacts osmolarity and indirectly influences GAL3ST2 activity by modulating the sphingolipid and glycosaminoglycan pathways. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Activates PI3K-Akt signaling, impacting glycosaminoglycan biosynthesis indirectly, hence influencing GAL3ST2. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Activates the LPA1 receptor, thereby indirectly affecting glycosaminoglycan biosynthesis and GAL3ST2 activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Acts as a precursor to various eicosanoids, which can indirectly influence GAL3ST2 through various metabolic pathways. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Affects estrogen receptors, indirectly influencing pathways that lead to modulation of GAL3ST2 activity. | ||||||