GAGE3 Activators
GAGE3 activators are compounds that could influence the expression and immunogenicity of the GAGE3 protein through epigenetic modifications or modulation of the immune response. Such compounds are not activators in the traditional sense of directly enhancing the function of a protein, but rather they can elevate the presence of GAGE3 by various mechanisms that lead to the increased transcription and translation of the GAGE3 gene or affect the presentation and recognition of GAGE3 peptides by the immune system.
For example, agents like DNA methyltransferase inhibitors and histone deacetylase inhibitors are known to cause the re-expression of epigenetically silenced genes in tumor cells. In the context of GAGE3, these compounds can reactivate the expression of this cancer-testis antigen, potentially leading to higher levels of GAGE3 protein in cells where it is typically not expressed or is underexpressed. Similarly, compounds that modify the immune response or the tumor microenvironment can lead to an increased recognition and processing of GAGE3 peptides, thereby indirectly influencing the overall levels and activity of GAGE3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can demethylate DNA and potentially upregulate the expression of genes like GAGE3 in cancer cells. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase inhibitor that can lead to a more open chromatin structure and potentially increase the expression of cancer-testis antigens. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, which may increase the expression of typically silenced genes in tumors, such as GAGE3. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
A histone deacetylase inhibitor that can lead to altered gene expression and potentially increase the presentation of antigens like GAGE3. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
As a histone deacetylase inhibitor, panobinostat can modify chromatin and influence the expression of various genes, including potentially GAGE3. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
A selective histone deacetylase inhibitor that can modulate gene expression and possibly affect the expression of cancer-testis antigens. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
A synthetic retinoid that can modulate gene expression through retinoic acid receptors, potentially affecting antigens like GAGE3. | ||||||
Bicalutamide | 90357-06-5 | sc-202976 sc-202976A | 100 mg 500 mg | $42.00 $146.00 | 27 | |
An androgen receptor antagonist that, by modifying androgenic signaling, may indirectly influence the expression of certain cancer-testis antigens. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Similar to bicalutamide, enzalutamide affects androgen receptor signaling and may alter the expression of genes like GAGE3. | ||||||