FucU Activators
The FucU Activators class encompasses a diverse group of chemicals that can indirectly upregulate FucU expression through various mechanisms. These chemicals target different components of signaling pathways that are known to negatively regulate FucU expression, such as the MAPK, PI3K/Akt, and TGF-β signaling pathways. By inhibiting key signaling molecules in these pathways, these chemicals can indirectly increase FucU expression.
For example, p38 MAPK inhibitors like SB205680 and PD98059 can indirectly upregulate FucU expression by suppressing the activation of p38 MAPK, a signaling protein that can negatively regulate FucU expression. Similarly, PI3K inhibitors like LY294002 and wortmannin can indirectly increase FucU expression by interfering with the PI3K/Akt signaling pathway, which can negatively regulate FucU expression. Additionally, TGF-β signaling inhibitors like SB431542, LY2109766, SB505124, and LDN-193189
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A small molecule inhibitor of p38 MAPK, a signaling protein that can negatively regulate FucU expression. By inhibiting p38 MAPK, SB205680 can indirectly upregulate FucU expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
A specific inhibitor of the MAPK kinase MEK1, which is upstream of p38 MAPK in the MAPK signaling pathway. PD98059 can indirectly increase FucU expression by blocking the activation of p38 MAPK. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A phosphatidylinositol 3-kinase (PI3K) inhibitor that can indirectly upregulate FucU expression by interfering with the PI3K/Akt signaling pathway, which can negatively regulate FucU expression. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that can indirectly increase FucU expression by blocking the PI3K/Akt signaling pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
A macrolide antibiotic that inhibits mTORC1, and can therefore indirectly increase FucU expression by blocking the mTORC1 signaling pathway. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
A specific inhibitor of TGF-β receptor kinase 1 (TβR1), a key signaling component in the TGF-β signaling pathway. SB431542 can indirectly upregulate FucU expression by blocking TGF-β signaling. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $327.00 $1377.00 | 2 | |
An inhibitor of the SMAD family of transcription factors, which are downstream effectors of TGF-β signaling. SB505124 can indirectly upregulate FucU expression by blocking SMAD-mediated transcriptional repression of FucU. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
An inhibitor of the SMAD4 transcription factor, which plays a critical role in TGF-β signaling. LDN-193189 can indirectly increase FucU expression by blocking SMAD4-mediated transcriptional repression of FucU. | ||||||