Date published: 2025-12-24

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FSTL5 Inhibitors

FSTL5 inhibitors represent a class of chemical compounds designed to specifically target and modulate the activity of FSTL5, also known as Follistatin-Like 5. FSTL5 is a secreted glycoprotein belonging to the Follistatin family and plays a pivotal role in regulating several critical cellular processes, particularly within the context of developmental biology, tissue homeostasis, and cell growth regulation. These inhibitors have gained considerable attention in the realm of molecular research and have shown promise in unraveling the intricacies of FSTL5-associated pathways. The primary mode of action of FSTL5 inhibitors revolves around their ability to interfere with the signaling cascades initiated by FSTL5. FSTL5 is known to interact with various cell surface receptors, including members of the TGF-β (Transforming Growth Factor-beta) superfamily, thereby modulating the downstream pathways associated with these receptors. FSTL5 inhibitors are designed to disrupt these interactions or inhibit the activity of specific kinases or receptors involved in FSTL5-mediated signaling. By doing so, these inhibitors can effectively dampen the effects of FSTL5 on cellular processes such as cell proliferation, differentiation, and extracellular matrix remodeling. Moreover, FSTL5 inhibitors are valuable tools for elucidating the intricate regulatory networks in which FSTL5 participates, shedding light on its role in normal physiology and implications in various disease contexts. Through meticulous research and experimentation, the scientific community aims to harness the ability of FSTL5 inhibitors to advance our understanding of fundamental biological processes and unveil novel opportunities in the future.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$75.00
$150.00
$215.00
$650.00
$1224.00
$4296.00
$7818.00
8
(1)

ALK5 Inhibitor II is a small molecule inhibitor that targets the TGF-β pathway by inhibiting the type I receptor kinases, blocking FSTL5 induction.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

SB-431542 is a selective inhibitor of the TGF-β receptor kinases, blocking signaling pathways mediated by FSTL5.

TGF-β RI Kinase Inhibitor V

627536-09-8sc-203294
2 mg
$86.00
3
(1)

TGF-β RI Kinase Inhibitor V (SD-208) is a small molecule inhibitor of TGF-βRI, preventing FSTL5 signaling by disrupting receptor kinase activity.

LY2157299

700874-72-2sc-391123
sc-391123A
5 mg
10 mg
$209.00
$352.00
3
(1)

Galunisertib (LY2157299) targets TGF-βRI, inhibiting FSTL5-induced TGF-β signaling and downstream effects.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$198.00
$650.00
16
(1)

A83-01 is a potent inhibitor of the TGF-β receptor ALK5, interfering with FSTL5-mediated signaling.

TGF-β RI Kinase Inhibitor VIII

356559-20-1sc-203295
2 mg
$100.00
2
(1)

TGF-β RI Kinase Inhibitor VIII selectively inhibits the TGF-β receptor ALK5, suppressing FSTL5-driven TGF-β pathways.

GW788388

452342-67-5sc-363544
sc-363544A
5 mg
25 mg
$95.00
$384.00
(0)

GW788388 inhibits TGF-β receptor kinases, reducing FSTL5-induced activation of the TGF-β pathway.