FSIP1 Activators
FSIP1 activators pertain to a chemical class designed to interact with and modulate the activity of the Fibrous Sheath Interacting Protein 1 (FSIP1). FSIP1 is a protein associated with the fibrous sheath structure of sperm flagella and cilia, which are cellular structures involved in movement and signal transduction. The fibrous sheath is a unique cytoskeletal structure that is critical for the correct assembly and function of these motile appendages. FSIP1 activators influence the function of FSIP1, which, in turn, has the potential to affect the stability, arrangement, and performance of microtubule-based structures within the flagella and cilia. The precise molecular mechanisms through which these activators exert their influence involve enhancing the interaction of FSIP1 with other proteins and cellular components, thereby modulating the dynamics of the fibrous sheath and its associated structures.
The development of FSIP1 activators is the result of intricate biochemical research that delves into the composition and regulation of the fibrous sheath. The fibrous sheath is composed of a complex matrix of proteins that provide structural support and serve as a scaffold for various enzymatic and regulatory processes. By targeting FSIP1, these activators can potentially influence the biochemical pathways that govern the assembly of the fibrous sheath, as well as its maintenance and function. The activity of FSIP1 activators is highly specific, reflecting a sophisticated level of control over the protein-protein interactions that define the behavior of ciliary and flagellar structures. Through direct engagement with FSIP1, these molecules can alter the conformational landscape of the protein, thereby influencing its ability to interact with other components within the fibrous sheath and modulating the overall biophysical properties of the structure. Understanding the action of FSIP1 activators at the molecular and cellular level provides valuable insights into the fundamental processes underpinning the motility and signaling functions of cilia and flagella.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which in turn activates PKA. This can lead to the phosphorylation of proteins involved in sperm development, which is the area where FSIP1 is functionally active. Increased PKA activity in this context is likely to enhance the activity of FSIP1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By preventing cAMP degradation, IBMX can indirectly enhance the PKA signaling pathway, which may promote the functional activity of FSIP1 involved in sperm flagellum development. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is essential for sperm formation, and zinc sulfate is a source of zinc ions. Zinc plays a role in the structural stability of proteins and may directly interact with FSIP1, which is known to be involved in the structural integrity of the sperm flagellum. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a substrate for nitric oxide synthase and is involved in the production of nitric oxide (NO). NO can increase cGMP levels, which may activate pathways that enhance the activity of FSIP1 in the sperm flagellum. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $180.00 | 13 | |
Tadalafil works similarly to Sildenafil by inhibiting PDE5, leading to increased cGMP levels. This can promote the activity of pathways where FSIP1 is involved, potentially enhancing FSIP1's role in sperm physiology. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a Rho-associated protein kinase (ROCK) inhibitor, which can alter actin cytoskeleton dynamics. Since FSIP1 is involved in the structural aspect of sperm, modulation of actin dynamics could enhance the structural role of FSIP1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with antioxidant properties. It can modulate signaling pathways involved in cell survival and proliferation. As FSIP1 is associated with sperm development, EGCG may enhance FSIP1 activity by influencing these pathways. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor of NAD+, which is crucial for cellular metabolism and energy production. Increased NAD+ levels may enhance FSIP1's activity indirectly by supporting the energy demands of developing sperm cells where FSIP1 functions. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. By mimicking cAMP in the cell, it can enhance the PKA signaling pathway and indirectly promote FSIP1 activity in sperm development and function. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions are cofactors for many enzymes, including those involved in phosphorylation. The availability of manganese could indirectly enhance the activity of FSIP1 by influencing enzymatic reactions that regulate sperm physiology. | ||||||