FRBZ1 Inhibitors
FRBZ1 Inhibitors are a series of chemical compounds that orchestrate the reduction of FRBZ1's functional activity through the modulation of signaling pathways intimately connected with FRBZ1's function. For instance, Rapamycin and Everolimus exert their influence by binding to FKBP12, creating a complex that inhibits the FRB domain of mTOR, which is analogous to that of FRBZ1, thereby curtailing the FRBZ1-dependent signaling cascade. WYE-354 and Torin 1, as selective mTOR inhibitors, contribute to the suppression of FRBZ1 activities by impairing mTORC1 and mTORC2 signaling pathways, which are structurally and functionally related to the FRBZ1 pathway. Compounds like PP242, AZD8055, and Sapanisertib, by serving as ATP-competitive inhibitors, strategically blockade the kinase domain of mTOR, subsequently diminishing FRBZ1's signaling due to the protein's structural mimicry to the mTOR's FRB domain.
Furthermore, PF-04691502's dual inhibition of PI3K/mTOR pathways, KU 0063794's selective targeting of mTOR kinase activity, and Palomid 529's inhibition of both TORC1/TORC2 pathways all indirectly lead to a decrease in FRBZ1 activity by dampening the downstream signaling pathways influenced by FRBZ1. OSU 03012 disrupts PDK1-mediated signaling within the PI3K/Akt/mTOR pathway, which, as a result, disrupts FRBZ1's involvement in these pathways. INK 128, another selective ATP-competitive mTOR inhibitor, works in a similar fashion to hamper the mTORC1/2 pathways, which in turn results in the indirect inhibition of FRBZ1 activity. Collectively, these FRBZ1 Inhibitors, through their focused effects on cellular signaling, ensure the downregulation of FRBZ1's functional activities without directly targeting the protein itself.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin binds to FKBP12 and the complex formed inhibits the FRB domain of mTOR, which is homologous to FRBZ1, leading to the inhibition of the FRBZ1-mediated signaling pathway. | ||||||
WYE-354 | 1062169-56-5 | sc-364652 sc-364652A | 10 mg 50 mg | $286.00 $1200.00 | ||
WYE-354 is a selective inhibitor of mTOR kinase activity, which effectively diminishes the mTOR signaling pathway including FRBZ1-dependent functions since FRBZ1 is structurally related to the FRB domain of mTOR. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is a selective ATP-competitive inhibitor of mTOR, which indirectly inhibits the function of FRBZ1 by targeting the kinase domain and preventing downstream signaling related to FRBZ1 activity. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is a potent and selective inhibitor of mTOR's kinase activity, which suppresses mTORC1 and mTORC2 signaling pathways, thereby diminishing FRBZ1 signaling due to its structural similarity to mTOR's FRB domain. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is an ATP-competitive inhibitor of mTOR kinase, which indirectly reduces FRBZ1 activity by inhibiting both mTORC1 and mTORC2 signaling complexes that share functional similarities with FRBZ1. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
KU 0063794 is a selective inhibitor of mTOR kinase activity, which leads to the inhibition of both mTORC1 and mTORC2 complexes, indirectly decreasing FRBZ1 activity through its structural and functional resemblance to the mTOR's FRB domain. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Palomid 529 is a dual TORC1/TORC2 inhibitor which indirectly inhibits the function of FRBZ1 by targeting the downstream signaling pathways that are also influenced by FRBZ1. | ||||||
OSU 03012 | 742112-33-0 | sc-364560 sc-364560A | 5 mg 25 mg | $109.00 $349.00 | 1 | |
OSU 03012 (also known as AR-12) inhibits PDK1 in the PI3K/Akt/mTOR pathway, which indirectly inhibits FRBZ1 function by disrupting signaling pathways that FRBZ1 is involved in due to its similarity with the FRB domain of mTOR. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $321.00 $1835.00 | ||
INK 128 is an inhibitor of mTOR kinase activity, which indirectly leads to the inhibition of FRBZ1 by targeting related signaling pathways that are involved in FRBZ1-mediated cellular functions. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
Everolimus selectively binds to FKBP12 and the resulting complex inhibits mTOR by interacting with its FRB domain, thereby indirectly inhibiting FRBZ1 signaling pathways due to the structural homology between FRBZ1 and the FRB domain of mTOR. | ||||||