FOXO6 Activators
FOXO6 activators are a category of compounds specifically designed to modulate the activity of the transcription factor FOXO6. As a member of the Forkhead box O family, FOXO6 is known for its role in regulating gene expression related to cellular processes such as metabolism, differentiation, proliferation, and apoptosis. Activation of FOXO6 can lead to transcriptional changes that influence these cellular events. The mechanism by which FOXO6 activators function may involve direct interaction with the protein, leading to a conformational change that promotes its translocation to the nucleus and binding to DNA at specific forkhead-responsive elements. Alternatively, activators may work indirectly by modulating upstream signaling pathways that control the phosphorylation state of FOXO6. Phosphorylation typically results in the export of FOXO6 from the nucleus and subsequent inhibition of its transcriptional activity; therefore, compounds that inhibit kinases responsible for FOXO6 phosphorylation can result in its activation.
The study of FOXO6 activators is of interest due to the protein's involvement in critical cellular functions and potential implications for understanding fundamental biological processes. By utilizing FOXO6 activators, scientists can probe the function of FOXO6 within various signaling networks, elucidate its role in the regulation of gene expression, and determine how activation of FOXO6 influences cell fate decisions. These activators provide valuable tools for dissecting the complex signaling cascades that govern cellular homeostasis and for exploring the intricate links between transcription factor activity and cellular outcomes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases cAMP levels. The elevation in cAMP levels activates protein kinase A (PKA), a known participant in the FOXO6 regulation pathway. PKA phosphorylation of FOXO6 enhances its activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin stimulates the PI3K/AKT pathway. Activation of this pathway leads to phosphorylation and activation of mTOR, which has been implicated in the modulation of FOXO6. This can lead to increased activity of FOXO6. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Despite its inhibitory action, in certain contexts, the inhibition of mTOR can induce a feedback activation of the PI3K/AKT pathway, which can then activate FOXO6. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
Metformin stimulates the AMPK pathway. Activation of this pathway can lead to the inhibition of mTOR, which may result in a feedback activation of the PI3K/AKT pathway, activating FOXO6. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol stimulates the SIRT1 pathway, which can activate PGC-1α. PGC-1α upregulates the expression of FOXO6, leading to its activation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin triggers the TRPV1 pathway. Activation of this pathway can lead to increases in intracellular calcium, which can activate calmodulin. Calmodulin activation can modulate FOXO6 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine stimulates the AMPK pathway, which leads to a decrease in mTOR activity. This can result in a feedback activation of the PI3K/AKT pathway, which can activate FOXO6. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG stimulates the AMPK pathway, which can lead to a decrease in mTOR activity. This can result in a feedback activation of the PI3K/AKT pathway, which can activate FOXO6. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $238.00 | ||
PQQ can activate the SIRT1/PGC-1α pathway. Activation of this pathway can upregulate the expression of FOXO6, leading to its activation. | ||||||