FOXO3 Inhibitors
FOXO3 inhibitors are chemical compounds that specifically target and inhibit the function of the Forkhead box O3 (FOXO3) transcription factor, a member of the Forkhead box O (FOXO) family. These transcription factors are characterized by their conserved Forkhead DNA-binding domain, which allows them to regulate the expression of various genes involved in cellular processes such as metabolism, apoptosis, cell cycle regulation, and oxidative stress response. Inhibition of FOXO3 activity can modulate these cellular pathways, altering the expression of downstream target genes. FOXO3 is known to be tightly regulated by post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which control its localization, stability, and activity in response to various stimuli. The design and function of FOXO3 inhibitors often focus on interfering with these regulatory mechanisms or directly preventing the transcription factor from binding to its target DNA sequences.
Structurally, FOXO3 inhibitors can vary significantly, as they can include small molecules, peptides, or other bioactive compounds. These inhibitors are designed to interact with specific domains of FOXO3 or its regulatory kinases and enzymes, such as AKT, which phosphorylates FOXO3, leading to its inactivation and cytoplasmic sequestration. Small-molecule inhibitors often achieve this by disrupting protein-protein interactions or by blocking the phosphorylation sites required for FOXO3's activation or nuclear localization. Understanding the chemical properties and interactions of these inhibitors is essential for their application in modulating the activity of FOXO3 in various experimental settings, particularly when studying pathways related to cellular stress, aging, and apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, a PI3K inhibitor, could lead to the phosphorylation of FOXO3, resulting in its translocation out of the nucleus, thereby decreasing its transcriptional activity and reducing its expression. | ||||||
AS 1842856 | 836620-48-5 | sc-507096 sc-507096A | 10 mg 50 mg | $97.00 $407.00 | ||
AS 1842856 specifically targets the forkhead transcription factors and could directly downregulate FOXO3 by inhibiting its DNA-binding capacity and promoting its proteasomal degradation. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
By inhibiting Akt, Triciribine could prevent FOXO3 phosphorylation, leading to its nuclear localization where it is less susceptible to degradation, but paradoxically, this may trigger a feedback loop that ultimately reduces FOXO3 expression. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
WZB117's inhibition of GLUT1 could decrease intracellular glucose levels, which may trigger a compensatory metabolic response that includes the downregulation of FOXO3 to conserve energy. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin's interaction with transcriptional coactivators and corepressors could lead to a reduced transcriptional activity of FOXO3, resulting in a decrease in its expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate's antioxidant properties could reduce oxidative stress within cells, which may suppress the induction of FOXO3 expression typically associated with cellular stress responses. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
By activating sirtuin pathways, Resveratrol could promote the deacetylation and subsequent activity alteration of FOXO3, potentially leading to a long-term decrease in FOXO3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin's antioxidant activity could lower the oxidative stress-mediated induction of FOXO3, thereby reducing its expression as part of a cellular defense mechanism. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
By activating the NRF2 pathway, DL-Sulforaphane may suppress the cellular stress response that often includes the upregulation of FOXO3, thus decreasing its expression levels. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin's hepatoprotective actions could attenuate hepatic stress signals that would otherwise elevate FOXO3 expression, leading to a more subdued expression level of this transcription factor. | ||||||