FNBP1L Inhibitors
Chemical inhibitors of FNBP1L target various aspects of the actin cytoskeleton, which is essential for the protein's function in cellular processes. Latrunculin A disrupts actin polymerization by binding to actin monomers, which in turn affects FNBP1L's ability to facilitate actin assembly. Similarly, Swinholide A sequesters actin dimers, preventing their incorporation into filaments, thus inhibiting FNBP1L's interaction with the actin cytoskeleton. Cytochalasin D binds to the growing ends of actin filaments, blocking their elongation, which hinders FNBP1L's cytoskeletal activities. Jasplakinolide, on the other hand, stabilizes filaments and inhibits their disassembly, creating an abnormal state of actin dynamics that can disrupt FNBP1L's normal function in reorganizing the cytoskeleton.
Beyond these actin-targeting agents, several inhibitors interfere with signaling pathways and proteins that modulate the actin cytoskeleton, thereby influencing FNBP1L's activity. Chelerythrine Chloride inhibits protein kinase C, a key player in actin organization, which can affect FNBP1L's associated activity. Y-27632 impedes the function of Rho-associated kinases, which are vital for actin cytoskeleton dynamics and, by extension, FNBP1L's function. ML-7 and Blebbistatin target myosin-related pathways; ML-7 by inhibiting myosin light chain kinase, and Blebbistatin by obstructing myosin II ATPase activity, which in both cases can inhibit FNBP1L's interaction with the cytoskeleton. Additionally, CK-636 and SMIFH2 hinder the formation of actin networks by inhibiting the Arp2/3 complex and formins, respectively, which are critical for FNBP1L's role in actin polymerization. Finally, Wortmannin, by inhibiting phosphoinositide 3-kinases, can affect FNBP1L's function due to PI3K's role in organizing the actin cytoskeleton.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers, preventing their polymerization. FNBP1L is involved in actin cytoskeleton reorganization; thus, latrunculin A inhibits FNBP1L's role in actin assembly. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A sequesters actin dimers and inhibits actin polymerization. Since FNBP1L functions in concert with actin dynamics, swinholide A inhibits FNBP1L's ability to interact with the cytoskeleton. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, blocking polymerization and elongation. This disruption in actin dynamics functionally inhibits FNBP1L's cytoskeletal interactions. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide stabilizes actin filaments and prevents their depolymerization. By altering actin dynamics, jasplakinolide can inhibit FNBP1L's role in actin cytoskeleton reorganization. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine Chloride is a potent inhibitor of protein kinase C (PKC). PKC is involved in actin cytoskeleton organization, and by inhibiting PKC, FNBP1L's interaction with actin dynamics is inhibited. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 selectively inhibits ROCK, a Rho-associated coiled-coil forming kinase that regulates actin cytoskeleton. Inhibition of ROCK disrupts actin assembly, influencing FNBP1L's cytoskeletal interactions. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). MLCK is key in actin-myosin contraction; by inhibiting MLCK, ML-7 can inhibit FNBP1L's interaction with the actin cytoskeleton. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits myosin II ATPase activity, thus impeding actin-myosin interactions. As FNBP1L is involved in actin-based processes, blebbistatin functionally inhibits FNBP1L's role in these processes. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of formin homology 2 domains on formins, which mediate actin nucleation and elongation. This inhibition disrupts actin dynamics, thereby inhibiting FNBP1L's associated activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). PI3Ks are involved in actin reorganization, and by inhibiting PI3K, FNBP1L's role in actin polymerization is inhibited. | ||||||