Flightless I Inhibitors
The class of Flightless I inhibitors comprises a diverse array of chemicals that modulate the function of Flightless I, a protein intricately involved in cellular processes related to actin dynamics, cytoskeletal organization, and cell motility. These inhibitors either directly target Flightless I or act indirectly by influencing specific signaling pathways associated with Flightless I. CK666, Latrunculin A, SMIFH2, Cytochalasin D, Blebbistatin, Y-27632, Jasplakinolide, CK-869, Brefeldin A, Latrunculin B, ML-7, and Cytoskeleton Biochem (CSK) Inhibitor represent a selection of chemicals with the ability to inhibit Flightless I or its associated pathways. CK666 and CK-869 are inhibitors of the Arp2/3 complex, critical regulators of actin polymerization. Flightless I interacts with actin filaments, and these inhibitors indirectly affect Flightless I-mediated processes related to cytoskeletal rearrangement, cell migration, and motility. Latrunculin A, Latrunculin B, SMIFH2, Cytochalasin D, and Jasplakinolide disrupt actin dynamics, directly impacting Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration.
Blebbistatin and ML-7 target myosin II and myosin light chain kinase (MLCK), respectively, influencing actomyosin dynamics and, consequently, Flightless I-mediated processes related to cytoskeletal rearrangement, cell motility, and migration. Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), a key regulator of actin cytoskeleton dynamics. This inhibitor indirectly affects Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration by modulating Rho GTPase signaling. Jasplakinolide directly targets actin polymerization, providing tools to investigate the specific impact of actin disruption on Flightless I function and cellular dynamics. These inhibitors collectively offer a comprehensive toolkit for researchers to dissect the intricate regulatory mechanisms of Flightless I, shedding light on its role in normal cellular physiology and implications in pathological conditions. The targeted inhibition of Flightless I or its associated pathways provides valuable tools for advancing our understanding of cellular dynamics and opens avenues for further investigations into the functional aspects of Flightless I in diverse cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK666 is an inhibitor of the Arp2/3 complex, a key regulator of actin polymerization. Flightless I is involved in actin dynamics, and CK666 inhibits the Arp2/3 complex, indirectly inhbibiting Flightless I-mediated processes related to cytoskeletal rearrangement, cell migration, and motility. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is a disruptor of actin polymerization by sequestering monomeric actin. Flightless I interacts with actin filaments, and Latrunculin A disrupts actin dynamics, inhbibiting Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a small molecule inhibitor that disrupts formin-mediated actin polymerization. Flightless I is implicated in actin dynamics, and SMIFH2 inhibits formin activity, indirectly inhibiting Flightless I-mediated processes related to cytoskeletal rearrangement, cell migration, and motility. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is a fungal metabolite that disrupts actin polymerization by capping the growing ends of actin filaments. Flightless I is associated with actin filaments, and Cytochalasin D disrupts actin dynamics, affecting Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a selective inhibitor of myosin II ATPase activity. Flightless I is involved in actomyosin dynamics, and Blebbistatin inhibits myosin II, indirectly inhbibiting Flightless I-mediated processes related to cytoskeletal rearrangement, cell motility, and migration. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK), a key regulator of actin cytoskeleton dynamics. Flightless I is linked to Rho GTPase signaling, and Y-27632 inhibits ROCK, indirectly inhbibiting Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is a natural product that stabilizes actin filaments. Flightless I interacts with actin, and Jasplakinolide stabilizes actin dynamics, influencing Flightless I-mediated cellular processes related to cytoskeletal rearrangement, cell migration, and motility. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is a small molecule inhibitor of the Arp2/3 complex, a regulator of actin polymerization. Flightless I is involved in actin dynamics, and CK-869 inhibits the Arp2/3 complex, indirectly inhibiting Flightless I-mediated processes related to cytoskeletal rearrangement, cell migration, and motility. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. Flightless I interacts with Golgi components, and Brefeldin A disrupts Golgi integrity, inhbibiting Flightless I-mediated cellular processes related to intracellular trafficking, vesicle formation, and Golgi-dependent signaling. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Latrunculin B is a toxin that binds to monomeric actin, preventing its polymerization. Flightless I is associated with actin filaments, and Latrunculin B disrupts actin dynamics, affecting Flightless I-mediated cellular processes related to cytoskeletal organization, cell motility, and migration. | ||||||