FKBP51 Activators
Common FKBP51 Activators include, but are not limited to Hydrocortisone CAS 50-23-7, Mifepristone CAS 84371-65-3, Rapamycin CAS 53123-88-9, FK-506 CAS 104987-11-3 and Dexamethasone CAS 50-02-2.
FKBP51, or FK506 binding protein 5, is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein interacts with various other proteins, acting as a co-chaperone in the regulation of steroid receptor complexes. It is known to have peptidylprolyl isomerase activity, which means it can catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. FKBP51's role in various cellular processes emphasizes its importance in maintaining cellular homeostasis.
FKBP51 Activators are a specific group of chemical compounds designed to enhance or stimulate the activity or expression of the FKBP51 protein. By promoting the activity of FKBP51, these activators influence a variety of intracellular processes where FKBP51 plays a pivotal role. For example, the modulation of steroid receptor complexes, which are crucial for various signaling pathways within cells, can be influenced by changes in FKBP51 activity. Furthermore, by affecting the peptidylprolyl isomerase activity of FKBP51, these activators may influence protein folding processes within the cell. Such alterations can have profound implications on cellular function, stability, and response to external stimuli. Understanding the mechanistic actions and outcomes of FKBP51 activators can provide deeper insights into cellular biology and the intricate balance of protein interactions and functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Cortisol, a glucocorticoid, can induce FKBP51 expression as part of its regulation of the glucocorticoid receptor pathway. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Mifepristone is a glucocorticoid receptor antagonist. By modulating the receptor's activity, it might influence FKBP51 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an immunosuppressant that binds FKBP51, rapamycin might modulate the expression of FKBP51. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK-506 binds to FKBP51. This interaction might influence the cellular levels of FKBP51. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, a synthetic glucocorticoid, can induce FKBP51 expression as part of its effect on the glucocorticoid receptor pathway. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone, an aldosterone antagonist, might influence FKBP51 expression through its modulation of steroid receptors. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $91.00 $255.00 | 32 | |
Temozolomide, a DNA alkylating agent, induces cellular stress, which might upregulate FKBP51 as a stress response protein. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
As a histone deacetylase inhibitor, valproic acid can modulate gene expression, potentially affecting FKBP51 levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane affects various cellular pathways, including NRF2-mediated oxidative stress responses, which might influence FKBP51 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, vorinostat, might influence FKBP51 expression by modulating chromatin structure and gene expression. | ||||||