FILIA Inhibitors

Given the information on Khdc3, the chemical class termed Khdc3 Inhibitors would include compounds that can modulate the activity of proteins and signaling pathways interconnected with the roles of Khdc3. These inhibitors are not specific to Khdc3 but can indirectly modulate its function through their actions on related molecular targets. The first group of inhibitors, including Olaparib, ATM Kinase Inhibitor, and ATR Kinase Inhibitor, can influence DNA replication and repair mechanisms where Khdc3 is known to recruit other proteins and sustain activities crucial for these processes. By altering the efficiency of PARP1, ATM, or ATR, these chemicals may impair Khdc3's ability to facilitate DNA repair.

The second group, consisting of compounds like Cytochalasin D, Rhosin, BI 2536, ZM447439, Nocodazole, and Mad2 Inhibitor-1, targets the cytoskeletal components and kinases involved in cell division. These chemicals can impact Khdc3's role in regulating actin dynamics, spindle assembly, and the spindle assembly checkpoint, which are essential for proper cell division and maintenance of euploidy. The third set of compounds, including NSC 23766, Forskolin, and Pifithrin-α, could impact Khdc3's function in neural stem cell differentiation and neurogenesis. By influencing the signaling pathways and transcription factors like p53 that are potentially involved with Khdc3's roles in neuronal development, these inhibitors may alter the normal progression of learning, memory, and anxiety development.