FIG4 Activators
The chemical class of FIG4 Activators consists of chemicals that indirectly influence the activity of the FIG4 protein. Even though direct activators of FIG4 are not well-identified, these chemicals can influence FIG4 activity by modulating the availability and metabolism of its substrate, PI(3,5)P2. They primarily function by altering the enzymes involved in the synthesis or degradation of PI(3,5)P2, such as PI3K and phospholipase C.
These chemicals predominantly fall into the category of enzyme inhibitors, specifically PI3K inhibitors, and lipid metabolites, which can influence the cellular lipid environment. The PI3K inhibitors, such as Wortmannin and LY294002, and the flavonoid Quercetin, function by reducing the production of PI(3,5)P2, indirectly influencing FIG4 activity. On the other hand, lipid metabolites like sphingosine can alter the cellular lipid environment and influence PI(3,5)P2 levels and indirectly the activity of FIG4. In summary, these chemicals alter the activity of FIG4 by modulating the availability and metabolism of its substrate, PI(3,5)P2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, the enzyme that produces PI(3,5)P2 from PIP2. By inhibiting PI3K, Wortmannin indirectly influences the availability of substrates for FIG4, thereby impacting FIG4 functions. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine may influence FIG4 by altering cellular lipid metabolism, which indirectly influences PI(3,5)P2 levels and consequently the activity of FIG4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another potent inhibitor of PI3K. By reducing PI(3,5)P2 production, it indirectly alters the activity of FIG4. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that can inhibit PI3K, thus potentially altering PI(3,5)P2 levels and indirectly influencing the activity of FIG4. | ||||||