FAM83D Activators
Family with Sequence Similarity 83, Member D (FAM83D) is a protein that has garnered attention for its role in the regulation of cell division and its involvement in the stabilization of the mitotic spindle. As a part of the FAM83 family, which is characterized by a conserved domain of unknown function (DUF1669), FAM83D plays a crucial role in the proper progression of the cell cycle, particularly during mitosis. The protein is predominantly localized to the centrosome and spindle apparatus during mitosis, where it is believed to facilitate the proper segregation of chromosomes by stabilizing spindle microtubules. This function is vital for ensuring genomic stability and preventing aneuploidy, a condition associated with numerous diseases. The precise molecular mechanisms through which FAM83D exerts its effects on spindle dynamics and chromosome segregation are subjects of ongoing research, but its association with key components of the mitotic machinery underscores its importance in cell division.
The activation of FAM83D involves a complex interplay of cellular signaling pathways that modulate its expression and function during the cell cycle. Activation is likely mediated through post-translational modifications, such as phosphorylation, which can alter its interaction with other proteins and its stability. Phosphorylation of FAM83D has been suggested to regulate its localization to the centrosome and spindle apparatus, thereby influencing its ability to participate in the stabilization of microtubules. Furthermore, the expression of FAM83D is subject to cell cycle-dependent regulation, with levels peaking during mitosis, suggesting that its activation is finely tuned in accordance with the cellular needs. This temporal regulation ensures that FAM83D is activated precisely when its function is required for mitotic progression, highlighting the sophisticated regulatory mechanisms that control cell division. The elucidation of the pathways and factors that govern FAM83D activation will provide valuable insights into the cellular mechanisms that maintain genomic integrity during cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
A peptide hormone that directly or indirectly activates the PI3K/Akt pathway, potentially increasing FAM83D expression or activity through downstream signaling. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
A small molecule that indirectly activates the Wnt/β-Catenin pathway, which may increase FAM83D expression or activity through its downstream effects on cellular processes. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
A compound that can indirectly activate the Hedgehog signaling pathway, potentially increasing FAM83D expression or function through downstream signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor; mTOR activators like Insulin or amino acids can activate the mTOR pathway, potentially increasing FAM83D through downstream signaling pathways involved in cell growth and proliferation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
A compound that can activate the AMP-Activated Protein Kinase (AMPK) pathway, potentially increasing FAM83D by regulating cellular energy homeostasis. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
An activator of the AMPK pathway, which can increase FAM83D expression or activity. | ||||||