FAM57A Activators
FAM57A Activators are a class of biochemical agents recognized for their role in modulating the function of the FAM57A gene product, a protein associated with lipid metabolism within the cellular environment. This class of activators functions at the molecular level, primarily through interactions with various lipid signaling pathways, which are critical for the maintenance of cellular lipid homeostasis. The FAM57A protein itself is an integral component of these complex pathways, and its activity is essential for the proper regulation of lipid composition in cell membranes and lipid signaling molecules. FAM57A Activators can be diverse in structure and function, encompassing a broad spectrum of molecules that range from endocannabinoids like anandamide to bioactive sphingolipids such as sphingosine-1-phosphate (S1P) and ceramide.
These activators operate by engaging with specific receptors or enzymes that govern the synthesis, degradation, or transformation of various lipid species. For instance, anandamide activates cannabinoid receptors which can influence the PI3K/Akt signaling pathway, a pathway known to be involved in the regulation of various cellular processes including lipid metabolism and signal transduction. On the other hand, molecules like S1P and ceramide interact with their respective receptors to initiate signaling cascades that can alter the cellular lipid environment, thereby modulating the activity of lipid-metabolizing enzymes and affecting the function of FAM57A. The mechanism of action for these activators often involves altering the levels of secondary messengers such as diacylglycerol (DAG) and inositol triphosphate (IP3), which are pivotal in the transmission of signals that dictate the metabolic fate of lipids within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P is a bioactive lipid that activates S1P receptors, leading to the activation of the MAPK/ERK pathway. As FAM57A is associated with lipid metabolism, S1P signaling can enhance its activity by altering the lipid environment in which FAM57A functions. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
LPA acts through G protein-coupled receptors to activate the phospholipase C (PLC) pathway, which results in the production of diacylglycerol (DAG) and inositol triphosphate (IP3), secondary messengers that can modulate lipid signaling pathways involving FAM57A. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $131.00 $300.00 | 10 | |
PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation and inflammation. PAF can enhance FAM57A activity through its role in modulating lipid signaling pathways and membrane dynamics. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramide can initiate a signaling cascade that leads to the activation of protein phosphatase 2A (PP2A) and the subsequent dephosphorylation of downstream targets. FAM57A, with its lipid-related functions, can be influenced by ceramide levels, enhancing its activity in lipid metabolism. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a polyunsaturated fatty acid that is released from membrane phospholipids and acts as a signaling molecule. It can enhance the activity of FAM57A by altering the lipid composition, which FAM57A is involved in regulating. | ||||||
R 59-022 | 93076-89-2 | sc-203227 | 5 mg | $124.00 | 1 | |
DAG is a secondary messenger produced by the hydrolysis of PIP2. DAG activates PKC, which can then influence lipid signaling pathways and membrane dynamics, thereby potentially enhancing the activity of FAM57A in lipid metabolism. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
OEA is a lipid signaling molecule that can activate peroxisome proliferator-activated receptor-alpha (PPAR-alpha). Activation of PPAR-alpha can lead to changes in lipid metabolism, thus enhancing the functional activity of FAM57A. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH is essential for the biosynthesis of fatty acids and cholesterol. It provides the reducing equivalents for the reactions catalyzed by reductases, potentially influencing the lipid composition and directly enhancing the activity of FAM57A. | ||||||
Palmitoylethanolamide | 544-31-0 | sc-202754 sc-202754A sc-202754B sc-202754C sc-202754D | 10 mg 50 mg 500 mg 1 g 10 g | $80.00 $243.00 $2091.00 $3339.00 $16657.00 | ||
PEA engages with several receptors and exerts a variety of biological effects, particularly related to lipid signaling pathways. Since FAM57A is involved in lipid metabolism, the presence of PEA can enhance FAM57A activity. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
DHA is a polyunsaturated omega-3 fatty acid involved in the regulation of membrane fluidity. It can influence signaling pathways related to lipid metabolism and thus enhance the activity of FAM57A, which is implicated in these processes. | ||||||