Date published: 2026-5-30

1-800-457-3801

SCBT Portrait Logo
Seach Input

FAM46D Inhibitors

Inhibitors of FAM46D operate through various biochemical mechanisms to decrease the functional activity of this protein. Kinase inhibitors, for instance, target a broad spectrum of kinases that phosphorylate numerous substrates, including FAM46D, thereby inhibiting its activity when these phosphorylation events are blocked. Similarly, inhibitors that target the heat shock protein 90 (Hsp90) destabilize client proteins, which could include FAM46D, thus reducing its stability and function. Proteasome inhibitors work by preventing the breakdown of ubiquitinated proteins, leading to an accumulation of regulatory proteins that could suppress FAM46D indirectly. Further indirect inhibition of FAM46D is achieved through the modulation of key signaling pathways upon which it depends. The PI3K/AKT signaling pathway, essential for various cellular processes, can be disrupted by specific inhibitors, leading to a downstream effect that diminishes the activity of FAM46D. MEK inhibitors that attenuate the MAPK pathway also have the potential to modulate the cellular environment, resulting in reduced FAM46D activity. Additionally, inhibitors of HDAC affect the acetylation status of chromatin and alter gene expression patterns, potentially affecting the transcriptional landscape of FAM46D. Inhibitors that disrupt cellular calcium signaling, such as those targeting the SERCA pump, may also indirectly affect the function of FAM46D if it is involved in calcium-dependent processes.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

A potent kinase inhibitor that targets multiple kinases involved in various signaling pathways, leading to the inhibition of FAM46D due to its reliance on phosphorylation for activity.

Geldanamycin

30562-34-6sc-200617B
sc-200617C
sc-200617
sc-200617A
100 µg
500 µg
1 mg
5 mg
$39.00
$59.00
$104.00
$206.00
8
(1)

An Hsp90 inhibitor, which leads to the degradation of client proteins and could result in decreased stability of FAM46D, indirectly reducing its functional activity.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

An inhibitor of eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, indirectly leading to the decrease in FAM46D levels.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially causing a buildup of proteins that could downregulate FAM46D indirectly.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor that impacts protein synthesis and autophagy, pathways in which FAM46D is involved, leading to decreased functional activity of FAM46D.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor that disrupts the AKT signaling pathway, indirectly leading to the inhibition of FAM46D activity as this pathway influences its function.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

An inhibitor of MEK, which is part of the MAPK pathway, leading to downstream effects that can inhibit FAM46D activity by altering the signaling environment it relies on.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

An HDAC inhibitor that alters chromatin structure and gene expression, potentially decreasing FAM46D activity by modifying its transcriptional environment.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to calcium dysregulation and potentially inhibiting FAM46D-related calcium signaling.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

A proteasome inhibitor which can lead to indirect inhibition of FAM46D through the accumulation of regulatory proteins that control its activity.