Date published: 2026-2-7

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FAM38B Inhibitors

The class of FAM38B inhibitors, or PIEZO2 inhibitors, would consist of compounds that can alter the function of the PIEZO2 ion channel. Since PIEZO2 is involved in the cellular response to physical forces, these compounds might modulate the channel's ability to open in response to mechanical stimuli. For instance, Ruthenium Red and GsMTx4 are known to non-specifically affect ion channels, including mechanosensitive channels, and could thus modulate PIEZO2. Gadolinium ions and other ions like La3+ are recognized for their ability to block mechanosensitive channels, which includes PIEZO2. Aminoglycosides such as streptomycin could affect PIEZO2 by blocking its pore or altering its gating mechanism. Compounds known to influence intracellular calcium levels, such as BAPTA-AM, SKF-96365, and calcium channel blockers like verapamil and nifedipine, could modify PIEZO2 activity due to the channel's permeability to calcium. These compounds could indirectly affect PIEZO2 function by changing the cellular ionic environment or the signaling pathways that regulate the channel's activity.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ruthenium red

11103-72-3sc-202328
sc-202328A
500 mg
1 g
$188.00
$250.00
13
(1)

A polycationic dye that non-selectively blocks certain ion channels; it may alter PIEZO2 function.

Gadolinium(III) chloride

10138-52-0sc-224004
sc-224004A
5 g
25 g
$153.00
$357.00
4
(1)

A lanthanide ion that blocks various mechanosensitive ion channels and might influence PIEZO2.

Streptomycin sulfate

3810-74-0sc-202821
sc-202821A
10 g
100 g
$92.00
$131.00
12
(1)

An aminoglycoside antibiotic that has been shown to block mechanosensitive channels, potentially affecting PIEZO2.

Amiloride • HCl

2016-88-8sc-3578
sc-3578A
25 mg
100 mg
$22.00
$57.00
6
(2)

A diuretic that also acts as a nonspecific blocker of certain ion channels, which might affect PIEZO2.

4-Methyl-2-(1-piperidinyl)-quinoline

5465-86-1sc-483337
25 mg
$430.00
(0)

A selective blocker of the TRPC4/TRPC5 channels, which may have off-target effects on other ion channels including PIEZO2.

YM 254890

568580-02-9sc-507356
1 mg
$510.00
(0)

A G protein inhibitor that could affect G-protein coupled signaling pathways influencing PIEZO2 activity.

SK&F 96365

130495-35-1sc-201475
sc-201475B
sc-201475A
sc-201475C
5 mg
10 mg
25 mg
50 mg
$103.00
$158.00
$397.00
$656.00
2
(1)

An inhibitor of receptor-mediated calcium entry channels that may also affect PIEZO2 function indirectly.

BAPTA/AM

126150-97-8sc-202488
sc-202488A
25 mg
100 mg
$138.00
$458.00
61
(2)

A cell-permeable calcium chelator that could modulate intracellular calcium levels and potentially influence PIEZO2 activity.

Sodium Tetrachloropalladate(II)

13820-53-6sc-296406
1 g
$132.00
(0)

A lanthanum ion known to block calcium channels, which might also affect calcium permeable mechanosensitive channels like PIEZO2.

Verapamil

52-53-9sc-507373
1 g
$374.00
(0)

A calcium channel blocker that might have off-target effects on PIEZO2 function given its role in ion transport.