FAM38B Activators
FAM38B Activators encompass a range of chemical compounds that indirectly enhance the functional activity of FAM38B, primarily in the realm of mechanotransduction and cytoskeletal organization. Forskolin, by increasing cAMP levels and subsequently activating PKA, indirectly modulates cellular mechanosensing pathways in which FAM38B is involved, thereby enhancing its role in cell mechanosensing and response. Similarly, Y-27632, as a ROCK inhibitor, alters cytoskeletal dynamics, indirectly benefiting FAM38B's function in mechanotransduction by changing cytoskeletal tension and cell morphology. Blebbistatin and ML-7, both influencing muscle contraction and cytoskeletal dynamics by inhibiting myosin II and myosin light chain kinase respectively, indirectly support FAM38B's role in cell shape and motility, essential aspects of mechanotransduction.
Further contributing to the activation of FAM38B, stabilizers and disruptors of actin filaments like Jasplakinolide, Phalloidin, Latrunculin B, and Cytochalasin D play significant roles. Jasplakinolide and Phalloidin stabilize actin filaments, thereby indirectly enhancing FAM38B's function in cellular response to mechanical stress. In contrast, Latrunculin B and Cytochalasin D disrupt actin polymerization, which can also indirectly benefit FAM38B's role in mechanotransduction, as changes in actin dynamics are crucial for cell's mechanical sensing. Calyculin A, a phosphatase inhibitor, affects the phosphorylation state of proteins involved in cytoskeletal regulation, thus supporting FAM38B's activity in mechanosensing. Moreover, C3 Transferase and NSC 23766, which inhibit RhoA and Rac1 respectively, modulate cytoskeletal organization and cell motility, indirectly enhancing FAM38B's role in these processes. Finally, Wiskostatin, an inhibitor of N-WASP, affects actin polymerization, further contributing to the modulation of FAM38B's function in mechanotransduction. Collectively, these FAM38B Activators, through their targeted effects on cytoskeletal dynamics and cellular mechanosensing, facilitate the enhancement of FAM38B-mediated processes essential for cell's response to mechanical stimuli.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A ROCK inhibitor that modulates cytoskeletal dynamics. Since FAM38B is involved in mechanotransduction and cytoskeletal reorganization, inhibition of ROCK can indirectly enhance FAM38B's role in these processes by altering cytoskeletal tension and cell morphology. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
An inhibitor of myosin II, affecting muscle contraction and cell motility. By modulating these processes, blebbistatin can indirectly enhance FAM38B's function in mechanotransduction, as FAM38B is linked to cell shape and motility. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A stabilizer of actin filaments, influencing cell morphology and motility. By stabilizing actin, jasplakinolide can indirectly enhance FAM38B's role in mechanotransduction and cellular response to mechanical stress. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
An inhibitor of myosin light chain kinase (MLCK), impacting cytoskeletal dynamics. ML-7, by altering actin-myosin interactions, can indirectly enhance FAM38B's function in mechanotransduction and cellular response to mechanical stimuli. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
A phosphatase inhibitor that affects cytoskeletal regulation. By altering the phosphorylation state of proteins involved in cytoskeletal dynamics, Calyculin A can indirectly enhance FAM38B's role in mechanotransduction. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
A Rac1 inhibitor, impacting cell motility and cytoskeletal organization. NSC 23766's inhibition of Rac1 can indirectly enhance FAM38B's role in cell shape and mechanotransduction processes. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments, affecting cell morphology and motility. By stabilizing actin, phalloidin can indirectly support FAM38B's function in cellular response to mechanical stress and mechanotransduction. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
An inhibitor of N-WASP, affecting actin polymerization and cell motility. By modulating actin dynamics, Wiskostatin can indirectly enhance FAM38B's role in mechanotransduction. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Disrupts actin filaments, influencing cell morphology and mechanosensing. Latrunculin B's effect on actin can indirectly enhance FAM38B's function in mechanotransduction and cellular response to mechanical stimuli. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
An inhibitor of actin polymerization, impacting cell shape and motility. By altering the actin cytoskeleton, Cytochalasin D can indirectly support FAM38B's role in mechanotransduction and the cellular response to mechanical stress. | ||||||