FAM195B Inhibitors
Chemical inhibitors of MAPK regulated corepressor interacting protein 1 act through various mechanisms to impede its function by targeting different kinases that are upstream in the signaling pathways. PD98059 and U0126 are notable for their role in inhibiting MEK1/2, which subsequently prevent the activation of ERK1/2. Normally, ERK1/2 phosphorylates MAPK regulated corepressor interacting protein 1, so the action of PD98059 and U0126 results in the inhibition of this phosphorylation process. Similarly, SL327, PD184352, and PD0325901 are MEK inhibitors that block MEK's ability to phosphorylate ERK, thereby inhibiting the activation of MAPK regulated corepressor interacting protein 1 through the same pathway.
In addition to MEK inhibitors, other chemicals target different kinases that interact with MAPK regulated corepressor interacting protein 1. SP600125, for instance, inhibits JNK, and by doing so, it interrupts the phosphorylation cascade that could involve MAPK regulated corepressor interacting protein 1. SB203580 specifically inhibits p38 MAP kinase, which is another potential kinase involved in the phosphorylation of MAPK regulated corepressor interacting protein 1. LY294002 and Wortmannin are inhibitors of the PI3K/Akt pathway, where their action leads to a reduction in the phosphorylation of a variety of proteins that could include MAPK regulated corepressor interacting protein 1. Rapamycin inhibits mTOR, a central molecule in cell signaling, which could also affect the function of MAPK regulated corepressor interacting protein 1. PP2 targets the Src family kinases, which are involved in multiple signaling processes, including those that could regulate MAPK regulated corepressor interacting protein 1. Lastly, Bisindolylmaleimide I inhibits protein kinase C (PKC), which is implicated in several signaling pathways and could have an influence on the function of MAPK regulated corepressor interacting protein 1. Each of these inhibitors, by targeting specific kinases in various signaling pathways, contributes to the inhibition of MAPK regulated corepressor interacting protein 1's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of extracellular signal-regulated kinases (ERKs). Inhibition of MEK by PD98059 prevents the activation of ERKs, which are known to phosphorylate MAPK regulated corepressor interacting protein 1, thus leading to its functional inhibition. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 functions similarly to PD98059 by inhibiting MEK1/2, thereby preventing the activation of ERK1/2. As ERKs can phosphorylate MAPK regulated corepressor interacting protein 1, the inhibition by U0126 reduces the activation and consequently the function of MAPK regulated corepressor interacting protein 1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which may phosphorylate substrates that interact with or regulate the activity of MAPK regulated corepressor interacting protein 1. By inhibiting JNK, SP600125 indirectly leads to the inhibition of MAPK regulated corepressor interacting protein 1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. The p38 MAPK pathway can be involved in phosphorylation processes that include MAPK regulated corepressor interacting protein 1. Inhibition by SB203580 can therefore lead to reduced phosphorylation and inhibition of MAPK regulated corepressor interacting protein 1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway. PI3K and Akt are involved in multiple signaling pathways that can phosphorylate and regulate proteins like MAPK regulated corepressor interacting protein 1. By inhibiting PI3K/Akt, LY294002 can indirectly inhibit the function of MAPK regulated corepressor interacting protein 1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. It prevents PI3K from activating Akt, which then leads to a decrease in the downstream phosphorylation of several proteins, potentially including MAPK regulated corepressor interacting protein 1, thus inhibiting its function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a central protein in cell signaling that can affect many downstream proteins, possibly including MAPK regulated corepressor interacting protein 1. Inhibition of mTOR by Rapamycin can indirectly lead to decreased activity of MAPK regulated corepressor interacting protein 1. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family kinases. These kinases can phosphorylate a range of substrates that may interact with MAPK regulated corepressor interacting protein 1. PP2, by inhibiting Src kinases, can indirectly inhibit the functional activity of MAPK regulated corepressor interacting protein 1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a protein kinase C (PKC) inhibitor. PKC is involved in various signaling pathways, potentially affecting the function of MAPK regulated corepressor interacting protein 1. Inhibition of PKC by Bisindolylmaleimide I can lead to the functional inhibition of MAPK regulated corepressor interacting protein 1. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK and therefore inhibits ERK signaling. By inhibiting MEK, SL327 prevents the phosphorylation of substrates by ERK, which in turn could inhibit the activation and function of MAPK regulated corepressor interacting protein 1. | ||||||