FAM188B Inhibitors
FAM188B inhibitors encompass a diverse array of chemical compounds that, through various pathways, converge on the inhibition of the functional activity of FAM188B. Staurosporine, a broad-spectrum protein kinase inhibitor, may curtail FAM188B activity by obstructing necessary phosphorylation events critical for its function, while rapamycin targets mTOR signaling, potentially diminishing FAM188B's role in cell growth and proliferation if these processes are mTOR-dependent. Similarly, LY294002 and Wortmannin exert their inhibitory effects through blockade of the PI3K/AKT pathway, a key signaling cascade that, if associated with FAM188B's function, would lead to a reduction in its cellular activities related to survival and metabolism. Compounds like U0126 and PD98059 specifically target the MEK enzymes upstream of ERK, which, if connected to FAM188B, would result in a downregulation of its activity in differentiation or proliferation.
Further refining the modulation of FAM188B are inhibitors that affect specific aspects of cellular signaling. SB203580 and SP600125, inhibitors of p38 MAPK and JNK respectively, could decrease FAM188B activity by mitigating stress response and apoptotic signaling pathways. Ibrutinib, by inhibiting Bruton's tyrosine kinase, could downregulate FAM188B activity involved in B-cell receptor signaling and development. Bortezomib, through proteasome inhibition, could lead to an accumulation of regulatory proteins and potentially decrease FAM188B activity related to cell cycle and apoptosis. Axitinib may impede FAM188B activity involved in angiogenesis by targeting the VEGF receptor tyrosine kinases. Lastly, Palbociclib, a selective inhibitor of CDK4/6, could suppress FAM188B function in cell cycle control, assuming FAM188B's activity is connected to the regulatory processes governed by these kinases. Collectively, these inhibitors demonstrate the complexity and interconnectivity of cellular pathways that govern the activity of FAM188B, and highlight the intricate nature of its regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which can influence FAM188B by downregulating signaling pathways that rely on phosphorylation events. If FAM188B activity is contingent upon phosphorylation, staurosporine may decrease its functional activity by preventing these necessary modifications. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation. If FAM188B function is related to mTOR signaling, rapamycin could decrease FAM188B activity by inhibiting the downstream effects of mTOR activation, which may include the modulation of FAM188B's role in cell cycle progression or growth. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can indirectly affect FAM188B by altering the PI3K/AKT pathway, which is involved in cell survival and metabolism. If FAM188B's function is downstream of PI3K/AKT signaling, LY294002 could decrease FAM188B activity by inhibiting this pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of the ERK pathway. By inhibiting MEK, U0126 may reduce ERK pathway signaling, which could indirectly lead to decreased activity of FAM188B if its function is associated with ERK pathway-mediated cellular processes, such as differentiation or proliferation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. If FAM188B activity is connected to stress responses mediated by p38 MAPK signaling, inhibition by SB203580 would result in decreased FAM188B activity due to reduced stress response signaling, potentially affecting processes like inflammation or apoptosis where FAM188B might play a role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is implicated in the control of apoptosis. If FAM188B has a role in apoptotic signaling pathways that involve JNK, the use of SP600125 could result in decreased activity of FAM188B by blocking JNK-mediated signaling events. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which functions upstream of the MAPK/ERK pathway. If FAM188B is regulated through the MAPK/ERK pathway, PD98059 could decrease its activity by inhibiting signaling through this pathway, which could affect cell cycle regulation or cell proliferation where FAM188B is potentially involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor, similar to LY294002, and would decrease FAM188B activity through the same mechanism, assuming FAM188B is downstream of PI3K/AKT signaling. It would thereby inhibit various cellular processes like growth, survival, and metabolism that could involve FAM188B. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor. If FAM188B is involved in B-cell receptor signaling where BTK plays a critical role, ibrutinib would lead to decreased FAM188B activity by inhibiting BTK and subsequent signaling events necessary for B-cell development and function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. If FAM188B is regulated via proteasomal degradation, bortezomib could affect its activity by altering the turnover rate of FAM188B or of key regulatory proteins within its signaling pathway, potentially leading to decreased function of FAM188B in processes like cell cycle progression or apoptosis. | ||||||