Date published: 2026-4-3

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FADS2 Inhibitors

FADS2, a key enzyme in the desaturation of fatty acids, can be modulated by a variety of chemical inhibitors. Among them, sc-26196, CAY10566, and sc-26196A are direct FADS2 inhibitors, targeting the enzymatic activity responsible for fatty acid desaturation. These compounds directly interfere with the conversion of precursor fatty acids into more unsaturated forms, impacting cellular lipid composition. Delta-Tocotrienol, a natural compound, serves as an indirect modulator of FADS2 by downregulating the transcriptional activity of SREBP-1c, leading to decreased FADS2 expression. Fasnall, on the other hand, indirectly influences FADS2 by inhibiting fatty acid synthase (FASN), disrupting de novo fatty acid synthesis and affecting the substrate availability for FADS2-mediated desaturation.PF-3845, a small molecule inhibitor, indirectly modulates FADS2 through its impact on endocannabinoid metabolism. By inhibiting MAGL, PF-3845 increases monoacylglycerol levels, potentially influencing FADS2 activity and altering fatty acid desaturation. Perilla oil extract, rich in omega-3 fatty acids, indirectly affects FADS2 by providing a surplus of alpha-linolenic acid (ALA), a substrate for FADS2-mediated desaturation. A939572, BRD7389, BMS-309403, and T863 are indirect FADS2 modulators that target the sterol regulatory element-binding proteins (SREBPs) or PPARα pathway. These compounds influence the expression of FADS2, impacting fatty acid desaturation and altering cellular lipid profiles. In summary, the diverse mechanisms of action exhibited by these FADS2 inhibitors provide valuable tools for researchers to explore the intricate pathways regulating fatty acid desaturation and its implications in cellular lipid metabolism.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SC 26196

218136-59-5sc-361350
sc-361350A
10 mg
50 mg
$158.00
$630.00
3
(0)

SC 26196 acts as a selective modulator of fatty acid desaturase 2 (FADS2), influencing lipid metabolism through its unique interactions with the enzyme's active site. This compound exhibits a distinct mechanism of action, enhancing the conversion of saturated fatty acids to unsaturated forms. Its kinetic profile reveals a competitive inhibition pattern, allowing for precise regulation of desaturation pathways. The compound's structural features facilitate specific binding, impacting overall lipid composition and cellular signaling.

CP 24,879 (hydrochloride)

10141-51-2sc-205269
sc-205269A
sc-205269B
sc-205269C
1 mg
5 mg
10 mg
50 mg
$39.00
$171.00
$300.00
$1321.00
1
(0)

CP 24,879 (hydrochloride) serves as a potent modulator of fatty acid desaturase 2 (FADS2), engaging in unique molecular interactions that alter lipid biosynthesis. Its distinct binding affinity promotes the transformation of saturated fatty acids, influencing metabolic pathways. The compound exhibits a non-competitive inhibition mechanism, allowing it to fine-tune desaturation rates. Additionally, its physicochemical properties enhance solubility, optimizing its interaction with lipid membranes and cellular components.

Conjugated Linoleic Acid (9Z,11E)

2540-56-9sc-205264
sc-205264A
sc-205264B
sc-205264C
sc-205264D
10 mg
50 mg
100 mg
1 g
10 g
$149.00
$577.00
$1007.00
$3751.00
$27056.00
(0)

Conjugated Linoleic Acid (9Z,11E) acts as a selective modulator of fatty acid desaturase 2 (FADS2), facilitating unique enzymatic pathways that influence lipid metabolism. Its structural conformation allows for specific interactions with the active site of FADS2, promoting the conversion of fatty acids through a competitive inhibition mechanism. This compound's unique stereochemistry enhances its affinity for lipid bilayers, impacting membrane fluidity and cellular signaling processes.

CAY 10566

944808-88-2sc-205109
sc-205109A
sc-205109B
1 mg
5 mg
25 mg
$117.00
$512.00
$1527.00
4
(1)

CAY10566 is a small molecule FADS2 inhibitor that interferes with the desaturation process of fatty acids. It directly binds to FADS2, disrupting its enzymatic activity in the conversion of fatty acids. This direct inhibition alters the fatty acid profile by limiting the formation of more unsaturated fatty acids, impacting cellular lipid metabolism and signaling.

δ-Tocotrienol

25612-59-3sc-205547
sc-205547A
1 mg
5 mg
$49.00
$203.00
1
(1)

δ-Tocotrienol is a natural compound that indirectly modulates FADS2 by influencing the expression of the enzyme. It downregulates the transcriptional activity of SREBP-1c, a key regulator of lipid metabolism, leading to decreased FADS2 expression.

BRD 7389

376382-11-5sc-361129
sc-361129A
10 mg
50 mg
$181.00
$714.00
(0)

BRD7389 is a chemical compound that indirectly influences FADS2 by targeting the sterol regulatory element-binding proteins (SREBPs). It inhibits the processing of SREBPs, leading to decreased transcriptional activation of FADS2. This indirect modulation impacts fatty acid desaturation, altering the cellular lipid composition and potentially affecting signaling pathways reliant on specific fatty acids.

FABP4 Inhibitor

300657-03-8sc-202606
5 mg
$208.00
2
(1)

FABP4 Inhibitor (BMS-309403) is a chemical compound that indirectly influences FADS2 by targeting the sterol regulatory element-binding proteins (SREBPs). It inhibits the processing of SREBPs, leading to decreased transcriptional activation of FADS2. This indirect modulation affects fatty acid desaturation, altering the cellular lipid composition and potentially impacting signaling cascades dependent on specific fatty acids.