Molecular structure of CP 24,879 (hydrochloride), CAS Number: 10141-51-2
CP 24,879 (hydrochloride) (CAS 10141-51-2)
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Alternate Names:
p-(Isopentyloxy)-aniline
Application:
CP 24,879 (hydrochloride) is an inhibitor of arachidonic acid biosynthesis
CAS Number:
10141-51-2
Molecular Weight:
215.80
Molecular Formula:
C11H17NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CP 24,879 (hydrochloride) is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of FADS1/FADS2 (Delta5/Delta6 desaturase). Mice injected with CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency. Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition.
CP 24,879 (hydrochloride) (CAS 10141-51-2) References
- Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. | Levin, G., et al. 2002. Biochem J. 365: 489-96. PMID: 11939906
- Delayed production of arachidonic acid contributes to the delay of proteinase-activated receptor-1 (PAR1)-triggered prostaglandin E2 release in rat gastric epithelial RGM1 cells. | Sekiguchi, F., et al. 2011. J Cell Biochem. 112: 909-15. PMID: 21328464
- Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. | López-Vicario, C., et al. 2014. Gut. 63: 344-55. PMID: 23492103
- Synthesis of docosahexaenoic acid from eicosapentaenoic acid in retina neurons protects photoreceptors from oxidative stress. | Simón, MV., et al. 2016. J Neurochem. 136: 931-46. PMID: 26662863
- Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches. | Shakya, S., et al. 2021. Acta Neuropathol Commun. 9: 101. PMID: 34059134
- Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. | Obukowicz, MG., et al. 1998. Biochem Pharmacol. 55: 1045-58. PMID: 9605428
Inhibitor of:
Enzyme, FADS1, and FADS2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CP 24,879 (hydrochloride), 1 mg | sc-205269 | 1 mg | $38.00 | |||
CP 24,879 (hydrochloride), 5 mg | sc-205269A | 5 mg | $168.00 | |||
CP 24,879 (hydrochloride), 10 mg | sc-205269B | 10 mg | $294.00 | |||
CP 24,879 (hydrochloride), 50 mg | sc-205269C | 50 mg | $1295.00 |