CP 24,879 (hydrochloride) CAS: 10141-51-2
MF: C11H18ClNO
MW: 215.8
An inhibitor of arachidonic acid biosynthesis.

CP 24,879 (hydrochloride) (CAS 10141-51-2)

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Synonym: p-(Isopentyloxy)-aniline
Application: An inhibitor of arachidonic acid biosynthesis
CAS Number: 10141-51-2
Molecular Weight: 215.8
Molecular Formula: C11H18ClNO
* Refer to Certificate of Analysis for lot specific data (including water content).
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Essential fatty acid deficiency symptoms include immune system depression and a general state of inflammatory inhibition. CP 24,879 is an inhibitor of arachidonic acid biosynthesis acting via the inhibition of Δ5/Δ6 desaturase. Mice injected with CP 24,879 at 3 mg/kg had a reduction of liver arachidonate content of approximately 50%. Murine mastocytoma cells treated with 5 µM CP 24,879 showed increased mead acid content and nearly complete ablation of leukotriene C4 synthesis, consistent with a desaturase inhibition-induced state of essential fatty acid deficiency.


References

1 Obukowicz, M.G., Raz, A., Pyla, P.D., et al. Identification and characterization of a novel Δ6/Δ5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. Biochem Pharmacol 55 1045-1058 (1998). 2 Levin, G., Duffin, K.L., Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochem J 365 489-496 (2002).

Physical State :
Solid
Solubility :
Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), 1: 3 solution of ethanol: PBS (pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml at 25.0° C).
Storage :
Store at -20° C
Melting Point :
154-159° C
Boiling Point :
322.1° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16078965
MDL Number :
MFCD05863938
SMILES :
CC(C)CCOC1=CC=C(C=C1)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Could I please be quoted for the item: CP 24,879 (hydrocholride), 1mg cat# sc-205269

Asked by: Deanna13
Thank you for your question. For accurate availability, shipping and pricing information regarding our chemical products, or to receive a quote, please contact Customer Service or reach out directly to your local distributor.
Answered by: Tech Service
Date published: 2020-02-20
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