SC 26196 CAS: 218136-59-5
MF: C27H29N5
MW: 423.55
A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases.

SC 26196 (CAS 218136-59-5)

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Synonym: α,α-Diphenyl-4-[(3-pyridinylmethylene )amino]-1-piperazinepentanenitrile
Application: A selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases
CAS Number: 218136-59-5
Molecular Weight: 423.55
Molecular Formula: C27H29N5
* Refer to Certificate of Analysis for lot specific data (including water content).
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SC 26196 is a selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases.


References

1. Obukowicz, M G., et al., 1998. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. The Journal of pharmacology and experimental therapeutics. 287(1): 157-66. PMID: 9765335
2. Hansen-Petrik, Melissa B., et al., 2002. Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. Cancer letters. 175(2): 157-63. PMID: 11741743
3. Zhang, Lei., et al., 2010. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. Journal of biomolecular screening. 15(2): 169-76. PMID: 20086206

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml).
Storage :
Store at -20° C
Melting Point :
242.35° C (Predicted)
Boiling Point :
650.21° C at 760 mmHg (Predicted)
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Δ6 desaturase: IC50 = 0.2 µM; Δ5 desaturase: IC50 >200 µM; Δ9 desaturase: IC50 >200 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD11226148
SMILES :
C1=CC(=CN=C1)C=NN2CCN(CC2)CCCC(CN)(C3=CC=CC=C3)C4=CC=CC=C4

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Certificate of Analysis

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SC 26196  Product Citations

See how others have used SC 26196. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21945809  Espinosa-Neira, R. et al. 2011. Int. J. Biochem. Cell Biol. 43: 1782-1791.

Citations 1 to 1 of 1 total
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