Molecular structure of SC 26196, CAS Number: 218136-59-5
SC 26196 (CAS 218136-59-5)
See product citations (3)
Alternate Names:
α,α-Diphenyl-4-[(3-pyridinylmethylene )amino]-1-piperazinepentanenitrile
Application:
SC 26196 is a selective Δ6 desaturase inhibitor that displays selectivity over Δ5 and Δ9 desaturases
CAS Number:
218136-59-5
Molecular Weight:
423.55
Molecular Formula:
C27H29N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SC 26196 is a selective FADS2 (Delta6 desaturase) inhibitor that displays selectivity over Delta5 and Delta9 desaturases. It completely blocks the conversion of linoleic acid to arachidonic acid (AA). It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.
SC 26196 (CAS 218136-59-5) References
- Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | Obukowicz, M., et al. 1999. Lipids. 34 Suppl: S149. PMID: 10419129
- Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. | Hansen-Petrik, MB., et al. 2002. Cancer Lett. 175: 157-63. PMID: 11741743
- Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition. | Duffin, KL., et al. 2001. Lipids. 36: 1203-8. PMID: 11795852
- Effect of the delta6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells. | Harmon, SD., et al. 2003. Lipids. 38: 469-76. PMID: 12848296
- Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. | Hargrave-Barnes, KM., et al. 2008. Obesity (Silver Spring). 16: 2245-52. PMID: 18719641
- A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. | Zhang, L., et al. 2010. J Biomol Screen. 15: 169-76. PMID: 20086206
- Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. | Mulligan, CM., et al. 2014. J Gerontol A Biol Sci Med Sci. 69: 799-809. PMID: 24418793
- Docosapentaenoic Acid (22:5n-3) Downregulates mRNA Expression of Pro-inflammatory Factors in LPS-activated Murine Macrophage Like RAW264.7 Cells. | Tian, Y., et al. 2017. J Oleo Sci. 66: 1149-1156. PMID: 28924088
- Paradigm shift - Metabolic transformation of docosahexaenoic and eicosapentaenoic acids to bioactives exemplify the promise of fatty acid drug discovery. | Halade, GV., et al. 2018. Biotechnol Adv. 36: 935-953. PMID: 29499340
- Polyunsaturated Fatty Acid Biosynthesis Involving Delta8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. | Sibbons, CM., et al. 2018. Front Immunol. 9: 432. PMID: 29556240
- Inhibition of Delta-6 desaturase reduces fatty acid re-esterification in 3T3-L1 adipocytes independent of changes in n3-PUFA cellular content. | Wang, C., et al. 2022. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159160. PMID: 35421603
- Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage. | Molendijk, J., et al. 2022. Clin Transl Med. 12: e810. PMID: 35560527
- The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes. | Chen, E., et al. 2023. Lipids Health Dis. 22: 25. PMID: 36788618
- Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | Obukowicz, MG., et al. 1998. J Pharmacol Exp Ther. 287: 157-66. PMID: 9765335
Inhibitor of:
ACSL, ACSL4, ACSVL6, Coronin 1B, FADS1, FADS2, PGD2 synthase, and PGF2αR.Activator of:
IRS-2, OLIG2, and Slit1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SC 26196, 10 mg | sc-361350 | 10 mg | $155.00 | |||
SC 26196, 50 mg | sc-361350A | 50 mg | $630.00 |