Molecular structure of BRD 7389, CAS Number: 376382-11-5
BRD 7389 (CAS 376382-11-5)
Alternate Names:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione; 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Application:
BRD 7389 is inhibits p90 ribosomal S6 kinase (RSK)
CAS Number:
376382-11-5
Molecular Weight:
366.41
Molecular Formula:
C24H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BRD 7389 is a chemical compound that has been the subject of research in the field of oncology. It is a small molecule inhibitor of the BRD4 protein, which is involved in the regulation of gene expression and has been implicated in the development of various types of cancer. BRD 7389 has also been studied for its potential as a research tool for investigating the functions of BRD4 in cells and model organisms. Because BRD 7389 specifically targets BRD4, it can be used to study the effects of BRD4 inhibition on various cellular processes, such as gene expression, cell cycle regulation, and DNA damage repair.
BRD 7389 (CAS 376382-11-5) References
- Small-molecule inducers of insulin expression in pancreatic alpha-cells. | Fomina-Yadlin, D., et al. 2010. Proc Natl Acad Sci U S A. 107: 15099-104. PMID: 20696901
- EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors. | Park, YS. and Cho, NJ. 2012. Mol Cell Biochem. 370: 191-8. PMID: 22865467
- c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12 cells mediated through P90RSK. | Seow, KH., et al. 2013. BMC Neurosci. 14: 153. PMID: 24330599
- Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. | Choudhary, A., et al. 2014. PLoS One. 9: e95194. PMID: 24759943
- [Regulation of S100B expression during long term potentiation]. | Lisachev, PD., et al. 2014. Ross Fiziol Zh Im I M Sechenova. 100: 953-63. PMID: 25682687
- Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus. | Ramírez, D., et al. 2015. Mol Cell Endocrinol. 411: 28-37. PMID: 25892444
- Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. | Rawashdeh, O., et al. 2016. J Neurochem. 138: 731-45. PMID: 27246400
- Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor. | Langdon, CG., et al. 2017. Mol Cancer Ther. 16: 1041-1053. PMID: 28292938
- Chemical strategies for pancreatic β cell differentiation, reprogramming, and regeneration. | Ma, X. and Zhu, S. 2017. Acta Biochim Biophys Sin (Shanghai). 49: 289-301. PMID: 28338772
- p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis. | Theodosakis, N., et al. 2017. J Invest Dermatol. 137: 2187-2196. PMID: 28599981
- Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. | Park, YH., et al. 2020. Nat Immunol. 21: 857-867. PMID: 32601469
- RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit. | Chae, HD., et al. 2020. Oncotarget. 11: 2387-2403. PMID: 32637030
- Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication. | Man, CH., et al. 2022. Leukemia. 36: 1990-2001. PMID: 35624145
- TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner. | Shen, W., et al. 2022. Cancer Sci. 113: 3018-3031. PMID: 35635239
- Tension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration. | Hu, Y., et al. 2022. Cell Death Dis. 13: 856. PMID: 36209218
Inhibitor of:
ACSL, ACSL4, FADS2, GlcNAc kinase, Rsk, Rsk-1, Rsk-2, and Rsk-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRD 7389, 10 mg | sc-361129 | 10 mg | $177.00 | |||
BRD 7389, 50 mg | sc-361129A | 50 mg | $700.00 |