Date published: 2026-5-7

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F-Spondin Inhibitors

F-Spondin inhibitors are a specialized class of compounds that target and inhibit the activity of F-Spondin, a protein that plays a critical role in the development and maintenance of the nervous system. F-Spondin, also known as Spondin-1, is an extracellular matrix protein predominantly expressed in the embryonic floor plate, a structure crucial for the proper guidance of axons during neural development. By modulating the interactions between F-Spondin and its associated receptors or binding partners, F-Spondin inhibitors provide researchers with the ability to study the intricate processes involved in neural patterning, axon guidance, and synaptic formation.

These inhibitors are particularly valuable in research focused on understanding the complex signaling pathways that F-Spondin is involved in, such as those related to neuron outgrowth, cell adhesion, and the organization of the extracellular matrix. By inhibiting F-Spondin, scientists can dissect its role in these processes and gain insights into how it influences the structural and functional aspects of the nervous system. Additionally, F-Spondin inhibitors enable the exploration of how disruptions in F-Spondin activity might contribute to neurodevelopmental disorders or other conditions characterized by abnormal neural connectivity. This makes them indispensable tools for advancing our knowledge of neurobiology, particularly in areas related to the molecular mechanisms governing neural development and the establishment of neural circuits. Through the use of F-Spondin inhibitors, researchers can further elucidate the roles of extracellular matrix proteins in the central nervous system, enhancing our overall understanding of neural architecture and its regulation.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

XAV939

284028-89-3sc-296704
sc-296704A
sc-296704B
1 mg
5 mg
50 mg
$36.00
$117.00
$525.00
26
(1)

A tankyrase inhibitor that stabilizes Axin and inhibits Wnt signaling. It′s used in research to study the regulation of β-catenin in the Wnt pathway and to potentially disrupt spondin function.

Tirofiban, Hydrochloride

150915-40-5sc-208440
10 mg
$215.00
(1)

A non-peptide inhibitor of the fibrinogen receptor (integrin αIIbβ3). It is used clinically as an antiplatelet drug to reduce the risk of thrombosis and to potentially disrupt spondin function.

Y-27632 dihydrochloride

129830-38-2sc-216067
sc-216067A
1 mg
5 mg
$170.00
$439.00
5
(2)

A widely used selective inhibitor of ROCK. It has been instrumental in cell biology studies, particularly in the areas of cell motility and apoptosis and to potentially disrupt spondin function.

IWP-2

686770-61-6sc-252928
sc-252928A
5 mg
25 mg
$96.00
$292.00
27
(1)

Inhibits Wnt production and thereby Wnt signaling. IWP-2 is selective for porcupine (PORCN), a membrane-bound O-acyltransferase involved in Wnt processing and secretion and to potentially disrupt spondin function.

Cilengitide

188968-51-6sc-507335
5 mg
$215.00
(0)

A synthetic peptide that inhibits integrins αvβ3 and αvβ5. It is primarily investigated for its anti-angiogenic properties in cancer therapy and to potentially disrupt spondin function.

LGK 974

1243244-14-5sc-489380
sc-489380A
5 mg
50 mg
$359.00
$1295.00
2
(0)

A PORCN inhibitor used in cancer research, particularly to study tumors that are dependent on Wnt signaling for growth and survival and to potentially disrupt spondin function.